Cholestenol Delta-isomerase

cholestenol delta-isomerase
Identifiers
EC number	5.3.3.5
CAS number	37318-47-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a cholestenol Delta-isomerase (EC 5.3.3.5) is an enzyme that catalyzes the chemical reaction

5alpha-cholest-7-en-3beta-ol $\rightleftharpoons$ 5alpha-cholest-8-en-3beta-ol

Hence, this enzyme has one substrate, 5alpha-cholest-7-en-3beta-ol, and one product, 5alpha-cholest-8-en-3beta-ol.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is Delta7-cholestenol Delta7-Delta8-isomerase. This enzyme participates in biosynthesis of steroids.

References

• Wilton DC, Rahimtula AD, Akhtar M (1969). "The reversibility of the delta8-cholestenol-delta7-cholestenol isomerase reaction in cholesterol biosynthesis". Biochem. J. 114 (1): 71–3. PMC 1184797. PMID 5810070. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1184797.