Persistent aura without infarction
- Persistent aura without infarction
Persistent aura without infarction (PAWOI) is a little-known condition first described under the designation prolonged migraine aura status [Haas DC. Prolonged migraine aura status. Ann Neurol 1982; 11: 197-199] that is not yet fully understood. PAWOI is said to be a possible cause of a variety of neurological symptoms, including visual snow, loss of vision, increased afterimages, tinnitus, and others [ [http://www.migraine-aura.org/ Migraine Aura Foundation] ] . However the pathogenesis of PAWOI is unknown, in other words, it is not known exactly how the aforementioned symptoms are caused. Furthermore, it is not clear which medical examinations are useful in diagnosing PAWOI. At present, PAWOI is usually diagnosed solely based on the patient's present and past symptoms.Different medication has been tried as treatment, notably acetazolamide [Haan J, Sluis P, Sluis LH, Ferrari MD. Acetazolamide treatment for migraine aura status. Neurology 2000; 55: 1588-1589.] , valproate [Rothrock JF. Successful treatment of persistent migraine aura with divalproex sodium. Neurology 1997; 48: 261-262.] , lamotrigine [Chen WT, Fuh JL, Lu SR, Wang SJ. Persistent migrainous visual phenomena might be responsive to lamotrigine. Headache 2001; 41: 823-825.] , topiramate, and furosemide [Rozen TD. Treatment of a prolonged migrainous aura with intravenous furosemide. Neurology 2000; 55: 732-733.] .
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