CLDN4

Claudin 4, also known as CLDN4, is a human gene. It belongs to the group of claudins.

PBB_Summary
section_title =
summary_text = This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.cite web | title = Entrez Gene: CLDN4 claudin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1364| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kniesel U, Wolburg H |title=Tight junctions of the blood-brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=
*cite journal | author=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=
*cite journal | author=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088
*cite journal | author=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=
*cite journal | author=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=
*cite journal | author=Katahira J, Inoue N, Horiguchi Y, "et al." |title=Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin. |journal=J. Cell Biol. |volume=136 |issue= 6 |pages= 1239–47 |year= 1997 |pmid= 9087440 |doi=
*cite journal | author=Katahira J, Sugiyama H, Inoue N, "et al." |title=Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26652–8 |year= 1997 |pmid= 9334247 |doi=
*cite journal | author=Paperna T, Peoples R, Wang YK, "et al." |title=Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion. |journal=Genomics |volume=54 |issue= 3 |pages= 453–9 |year= 1999 |pmid= 9878248 |doi= 10.1006/geno.1998.5619
*cite journal | author=Morita K, Furuse M, Fujimoto K, Tsukita S |title=Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 511–6 |year= 1999 |pmid= 9892664 |doi=
*cite journal | author=Itoh M, Furuse M, Morita K, "et al." |title=Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351–63 |year= 2000 |pmid= 10601346 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Colegio OR, Van Itallie C, Rahner C, Anderson JM |title=Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 6 |pages= C1346–54 |year= 2003 |pmid= 12700140 |doi= 10.1152/ajpcell.00547.2002
*cite journal | author=Katoh M, Katoh M |title=CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 683–9 |year= 2004 |pmid= 12736707 |doi=
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Michl P, Barth C, Buchholz M, "et al." |title=Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. |journal=Cancer Res. |volume=63 |issue= 19 |pages= 6265–71 |year= 2003 |pmid= 14559813 |doi=

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