GABRA1

Gamma-aminobutyric acid (GABA) A receptor, alpha 1, also known as GABRA1, is a human gene.

PBB_Summary
section_title =
summary_text = GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.cite web | title = Entrez Gene: GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2554| accessdate = ]

ee also

* GABAA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Johnson KJ, Sander T, Hicks AA, "et al." |title=Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis. |journal=Genomics |volume=14 |issue= 3 |pages= 745–8 |year= 1992 |pmid= 1330891 |doi=10.1016/S0888-7543(05)80178-8
*cite journal | author=Schofield PR, Pritchett DB, Sontheimer H, "et al." |title=Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits. |journal=FEBS Lett. |volume=244 |issue= 2 |pages= 361–4 |year= 1989 |pmid= 2465923 |doi=10.1016/0014-5793(89)80563-0
*cite journal | author=Garrett KM, Duman RS, Saito N, "et al." |title=Isolation of a cDNA clone for the alpha subunit of the human GABA-A receptor. |journal=Biochem. Biophys. Res. Commun. |volume=156 |issue= 2 |pages= 1039–45 |year= 1988 |pmid= 2847710 |doi=10.1016/S0006-291X(88)80949-5
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Kang I, Lindquist DG, Kinane TB, "et al." |title=Isolation and characterization of the promoter of the human GABAA receptor alpha 1 subunit gene. |journal=J. Neurochem. |volume=62 |issue= 4 |pages= 1643–6 |year= 1994 |pmid= 8133292 |doi=
*cite journal | author=Tögel M, Mossier B, Fuchs K, Sieghart W |title=gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12993–8 |year= 1994 |pmid= 8175718 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Huang RQ, Dillon GH |title=Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin. |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 243–55 |year= 1998 |pmid= 9655866 |doi=
*cite journal | author=Serretti A, Macciardi F, Cusin C, "et al." |title=No interaction of GABA(A) alpha-1 subunit and dopamine receptor D4 exon 3 genes in symptomatology of major psychoses. |journal=Am. J. Med. Genet. |volume=88 |issue= 1 |pages= 44–9 |year= 1999 |pmid= 10050966 |doi=10.1002/(SICI)1096-8628(19990205)88:1<44::AID-AJMG8>3.0.CO;2-Y
*cite journal | author=Bonnert TP, McKernan RM, Farrar S, "et al." |title=theta, a novel gamma-aminobutyric acid type A receptor subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9891–6 |year= 1999 |pmid= 10449790 |doi=10.1073/pnas.96.17.9891
*cite journal | author=Serretti A, Lilli R, Lorenzi C, "et al." |title=Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders. |journal=Psychiatry research |volume=87 |issue= 1 |pages= 7–19 |year= 1999 |pmid= 10512150 |doi=10.1016/S0165-1781(99)00056-6
*cite journal | author=Cossette P, Liu L, Brisebois K, "et al." |title=Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. |journal=Nat. Genet. |volume=31 |issue= 2 |pages= 184–9 |year= 2002 |pmid= 11992121 |doi= 10.1038/ng885
*cite journal | author=Kumar S, Sieghart W, Morrow AL |title=Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. |journal=J. Neurochem. |volume=82 |issue= 1 |pages= 110–7 |year= 2002 |pmid= 12091471 |doi=10.1046/j.1471-4159.2002.00943.x
*cite journal | author=Trudell J |title=Unique assignment of inter-subunit association in GABA(A) alpha 1 beta 3 gamma 2 receptors determined by molecular modeling. |journal=Biochim. Biophys. Acta |volume=1565 |issue= 1 |pages= 91–6 |year= 2002 |pmid= 12225856 |doi=10.1016/S0005-2736(02)00512-6
*cite journal | author=Sarto I, Wabnegger L, Dögl E, Sieghart W |title=Homologous sites of GABA(A) receptor alpha(1), beta(3) and gamma(2) subunits are important for assembly. |journal=Neuropharmacology |volume=43 |issue= 4 |pages= 482–91 |year= 2002 |pmid= 12367595 |doi=10.1016/S0028-3908(02)00160-0
*cite journal | author=Jenkins A, Andreasen A, Trudell JR, Harrison NL |title=Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. |journal=Neuropharmacology |volume=43 |issue= 4 |pages= 669–78 |year= 2002 |pmid= 12367612 |doi=10.1016/S0028-3908(02)00175-2
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kash TL, Jenkins A, Kelley JC, "et al." |title=Coupling of agonist binding to channel gating in the GABA(A) receptor. |journal=Nature |volume=421 |issue= 6920 |pages= 272–5 |year= 2003 |pmid= 12529644 |doi= 10.1038/nature01280
*cite journal | author=Lin SK, Chen CK, Ball D, "et al." |title=Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder. |journal=Pharmacogenomics J. |volume=3 |issue= 6 |pages= 349–55 |year= 2004 |pmid= 14569258 |doi= 10.1038/sj.tpj.6500203
*cite journal | author=Mercik K, Pytel M, Mozrzymas JW |title=Recombinant alpha 1 beta 2 gamma 2 GABA(A) receptors expressed in HEK293 and in QT6 cells show different kinetics. |journal=Neurosci. Lett. |volume=352 |issue= 3 |pages= 195–8 |year= 2004 |pmid= 14625018 |doi=10.1016/j.neulet.2003.08.060

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