PPP2R1A

Protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform, also known as PPP2R1A, is a human gene.

PBB_Summary
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summary_text = This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.cite web | title = Entrez Gene: PPP2R1A protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5518| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=
*cite journal | author=Walter G, Ruediger R, Slaughter C, Mumby M |title=Association of protein phosphatase 2A with polyoma virus medium tumor antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 7 |pages= 2521–5 |year= 1990 |pmid= 2157202 |doi=
*cite journal | author=Hemmings BA, Adams-Pearson C, Maurer F, "et al." |title=alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. |journal=Biochemistry |volume=29 |issue= 13 |pages= 3166–73 |year= 1990 |pmid= 2159327 |doi=
*cite journal | author=Walter G, Ferre F, Espiritu O, Carbone-Wiley A |title=Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8669–72 |year= 1989 |pmid= 2554323 |doi=
*cite journal | author=McCright B, Virshup DM |title=Identification of a new family of protein phosphatase 2A regulatory subunits. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26123–8 |year= 1995 |pmid= 7592815 |doi=
*cite journal | author=Ruediger R, Hentz M, Fait J, "et al." |title=Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. |journal=J. Virol. |volume=68 |issue= 1 |pages= 123–9 |year= 1994 |pmid= 8254721 |doi=
*cite journal | author=Zolnierowicz S, Van Hoof C, Andjelković N, "et al." |title=The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. |journal=Biochem. J. |volume=317 ( Pt 1) |issue= |pages= 187–94 |year= 1996 |pmid= 8694763 |doi=
*cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, "et al." |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=
*cite journal | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873
*cite journal | author=Ruediger R, Fields K, Walter G |title=Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens. |journal=J. Virol. |volume=73 |issue= 1 |pages= 839–42 |year= 1999 |pmid= 9847399 |doi=
*cite journal | author=Groves MR, Hanlon N, Turowski P, "et al." |title=The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. |journal=Cell |volume=96 |issue= 1 |pages= 99–110 |year= 1999 |pmid= 9989501 |doi=
*cite journal | author=Hong Y, Sarge KD |title=Regulation of protein phosphatase 2A activity by heat shock transcription factor 2. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12967–70 |year= 1999 |pmid= 10224043 |doi=
*cite journal | author=Yan Z, Fedorov SA, Mumby MC, Williams RS |title=PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1021–9 |year= 2000 |pmid= 10629059 |doi=
*cite journal | author=Husi H, Ward MA, Choudhary JS, "et al." |title=Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. |journal=Nat. Neurosci. |volume=3 |issue= 7 |pages= 661–9 |year= 2000 |pmid= 10862698 |doi= 10.1038/76615
*cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956–67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956
*cite journal | author=Ruteshouser EC, Ashworth LK, Huff V |title=Absence of PPP2R1A mutations in Wilms tumor. |journal=Oncogene |volume=20 |issue= 16 |pages= 2050–4 |year= 2001 |pmid= 11360189 |doi= 10.1038/sj.onc.1204301
*cite journal | author=Lubert EJ, Hong Y, Sarge KD |title=Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 38582–7 |year= 2001 |pmid= 11504734 |doi= 10.1074/jbc.M106906200
*cite journal | author=Elder RT, Yu M, Chen M, "et al." |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007
*cite journal | author=Li X, Virshup DM |title=Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 546–52 |year= 2002 |pmid= 11856313 |doi=

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