CCNA1

Cyclin A1, also known as CCNA1, is a human gene.

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summary_text = The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.cite web | title = Entrez Gene: CCNA1 cyclin A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8900| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hall M, Bates S, Peters G |title=Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. |journal=Oncogene |volume=11 |issue= 8 |pages= 1581–8 |year= 1995 |pmid= 7478582 |doi=
*cite journal | author=Xu M, Sheppard KA, Peng CY, "et al." |title=Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8420–31 |year= 1994 |pmid= 7969176 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=O'Connor PM, Ferris DK, Pagano M, "et al." |title=G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. |journal=J. Biol. Chem. |volume=268 |issue= 11 |pages= 8298–308 |year= 1993 |pmid= 8463339 |doi=
*cite journal | author=Sweeney C, Murphy M, Kubelka M, "et al." |title=A distinct cyclin A is expressed in germ cells in the mouse. |journal=Development |volume=122 |issue= 1 |pages= 53–64 |year= 1996 |pmid= 8565853 |doi=
*cite journal | author=Yang R, Morosetti R, Koeffler HP |title=Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. |journal=Cancer Res. |volume=57 |issue= 5 |pages= 913–20 |year= 1997 |pmid= 9041194 |doi=
*cite journal | author=Wang H, Shao N, Ding QM, "et al." |title=BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. |journal=Oncogene |volume=15 |issue= 2 |pages= 143–57 |year= 1997 |pmid= 9244350 |doi= 10.1038/sj.onc.1201252
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Liu D, Matzuk MM, Sung WK, "et al." |title=Cyclin A1 is required for meiosis in the male mouse. |journal=Nat. Genet. |volume=20 |issue= 4 |pages= 377–80 |year= 1998 |pmid= 9843212 |doi= 10.1038/3855
*cite journal | author=Yang R, Müller C, Huynh V, "et al." |title=Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2400–7 |year= 1999 |pmid= 10022926 |doi=
*cite journal | author=Ravnik SE, Wolgemuth DJ |title=Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage. |journal=Dev. Biol. |volume=207 |issue= 2 |pages= 408–18 |year= 1999 |pmid= 10068472 |doi= 10.1006/dbio.1998.9156
*cite journal | author=Yang R, Nakamaki T, Lübbert M, "et al." |title=Cyclin A1 expression in leukemia and normal hematopoietic cells. |journal=Blood |volume=93 |issue= 6 |pages= 2067–74 |year= 1999 |pmid= 10068680 |doi=
*cite journal | author=Müller C, Yang R, Beck-von-Peccoz L, "et al." |title=Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11220–8 |year= 1999 |pmid= 10196209 |doi=
*cite journal | author=Ruffner H, Jiang W, Craig AG, "et al." |title=BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4843–54 |year= 1999 |pmid= 10373534 |doi=
*cite journal | author=Brown NR, Noble ME, Endicott JA, Johnson LN |title=The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. |journal=Nat. Cell Biol. |volume=1 |issue= 7 |pages= 438–43 |year= 2001 |pmid= 10559988 |doi= 10.1038/15674
*cite journal | author=Liu D, Liao C, Wolgemuth DJ |title=A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice. |journal=Dev. Biol. |volume=224 |issue= 2 |pages= 388–400 |year= 2000 |pmid= 10926775 |doi= 10.1006/dbio.2000.9776
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Müller-Tidow C, Bornemann C, Diederichs S, "et al." |title=Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology. |journal=FEBS Lett. |volume=490 |issue= 1-2 |pages= 75–8 |year= 2001 |pmid= 11172814 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Müller-Tidow C, Wang W, Idos GE, "et al." |title=Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. |journal=Blood |volume=97 |issue= 7 |pages= 2091–7 |year= 2001 |pmid= 11264176 |doi=

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