YWHAG

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, also known as YWHAG, is a human gene.

PBB_Summary
section_title =
summary_text = This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.cite web | title = Entrez Gene: YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7532| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Morrison D |title=14-3-3: modulators of signaling proteins? |journal=Science |volume=266 |issue= 5182 |pages= 56–7 |year= 1994 |pmid= 7939645 |doi=
*cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789
*cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013
*cite journal | author=Roth D, Morgan A, Martin H, "et al." |title=Characterization of 14-3-3 proteins in adrenal chromaffin cells and demonstration of isoform-specific phospholipid binding. |journal=Biochem. J. |volume=301 ( Pt 1) |issue= |pages= 305–10 |year= 1994 |pmid= 8037685 |doi=
*cite journal | author=Vincenz C, Dixit VM |title=14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 20029–34 |year= 1996 |pmid= 8702721 |doi=
*cite journal | author=Autieri MV, Haines DS, Romanic AM, Ohlstein EH |title=Expression of 14-3-3 gamma in injured arteries and growth factor- and cytokine-stimulated human vascular smooth muscle cells. |journal=Cell Growth Differ. |volume=7 |issue= 11 |pages= 1453–60 |year= 1997 |pmid= 8930394 |doi=
*cite journal | author=Ku NO, Liao J, Omary MB |title=Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. |journal=EMBO J. |volume=17 |issue= 7 |pages= 1892–906 |year= 1998 |pmid= 9524113 |doi= 10.1093/emboj/17.7.1892
*cite journal | author=Autieri MV, Carbone CJ |title=14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells. |journal=DNA Cell Biol. |volume=18 |issue= 7 |pages= 555–64 |year= 1999 |pmid= 10433554 |doi= 10.1089/104454999315105
*cite journal | author=Horie M, Suzuki M, Takahashi E, Tanigami A |title=Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23. |journal=Genomics |volume=60 |issue= 2 |pages= 241–3 |year= 1999 |pmid= 10486217 |doi= 10.1006/geno.1999.5887
*cite journal | author=Dorner C, Ullrich A, Häring HU, Lammers R |title=The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33654–60 |year= 1999 |pmid= 10559254 |doi=
*cite journal | author=Pierrat B, Ito M, Hinz W, "et al." |title=Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family. |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2680–7 |year= 2000 |pmid= 10785390 |doi=
*cite journal | author=Lizcano JM, Morrice N, Cohen P |title=Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 547–57 |year= 2001 |pmid= 10880354 |doi=
*cite journal | author=Rena G, Prescott AR, Guo S, "et al." |title=Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. |journal=Biochem. J. |volume=354 |issue= Pt 3 |pages= 605–12 |year= 2001 |pmid= 11237865 |doi=
*cite journal | author=Elder RT, Yu M, Chen M, "et al." |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007
*cite journal | author=Peyrl A, Weitzdoerfer R, Gulesserian T, "et al." |title=Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21). |journal=Electrophoresis |volume=23 |issue= 1 |pages= 152–7 |year= 2003 |pmid= 11824616 |doi= 10.1002/1522-2683(200201)23:1<152::AID-ELPS152>3.0.CO;2-T |doilabel=10.1002/1522-2683(200201)23:1152::AID-ELPS1523.0.CO;2-T
*cite journal | author=Johnson BA, Stehn JR, Yaffe MB, Blackwell TK |title=Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 18029–36 |year= 2002 |pmid= 11886850 |doi= 10.1074/jbc.M110465200
*cite journal | author=Yu T, Robb VA, Singh V, "et al." |title=The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins. |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 783–9 |year= 2002 |pmid= 11996670 |doi= 10.1042/BJ20020060
*cite journal | author=Graeser R, Gannon J, Poon RY, "et al." |title=Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. |journal=J. Cell. Sci. |volume=115 |issue= Pt 17 |pages= 3479–90 |year= 2003 |pmid= 12154078 |doi=
*cite journal | author=Nellist M, Goedbloed MA, de Winter C, "et al." |title=Identification and characterization of the interaction between tuberin and 14-3-3zeta. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39417–24 |year= 2002 |pmid= 12176984 |doi= 10.1074/jbc.M204802200

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