APOC1

Apolipoprotein C-I, also known as APOC1, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within an apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.cite web | title = Entrez Gene: APOC1 apolipoprotein C-I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=341| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shulman RS, Herbert PN, Wehrly K, Fredrickson DS |title=Thf complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins. |journal=J. Biol. Chem. |volume=250 |issue= 1 |pages= 182–90 |year= 1975 |pmid= 166984 |doi=
*cite journal | author=Lauer SJ, Walker D, Elshourbagy NA, "et al." |title=Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene. |journal=J. Biol. Chem. |volume=263 |issue= 15 |pages= 7277–86 |year= 1988 |pmid= 2835369 |doi=
*cite journal | author=Smit M, van der Kooij-Meijs E, Woudt LP, "et al." |title=Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene. |journal=Biochem. Biophys. Res. Commun. |volume=152 |issue= 3 |pages= 1282–8 |year= 1988 |pmid= 2897845 |doi=
*cite journal | author=Tata F, Henry I, Markham AF, "et al." |title=Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19. |journal=Hum. Genet. |volume=69 |issue= 4 |pages= 345–9 |year= 1985 |pmid= 2985493 |doi=
*cite journal | author=Davison PJ, Norton P, Wallis SC, "et al." |title=There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene for apo E. |journal=Biochem. Biophys. Res. Commun. |volume=136 |issue= 3 |pages= 876–84 |year= 1986 |pmid= 3013172 |doi=
*cite journal | author=Myklebost O, Rogne S |title=The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19. |journal=Hum. Genet. |volume=73 |issue= 4 |pages= 286–9 |year= 1986 |pmid= 3017837 |doi=
*cite journal | author=Jackson RL, Sparrow JT, Baker HN, "et al." |title=The primary structure of apolopoprotein-serine. |journal=J. Biol. Chem. |volume=249 |issue= 16 |pages= 5308–13 |year= 1974 |pmid= 4369340 |doi=
*cite journal | author=Knott TJ, Robertson ME, Priestley LM, "et al." |title=Characterisation of mRNAs encoding the precursor for human apolipoprotein CI. |journal=Nucleic Acids Res. |volume=12 |issue= 9 |pages= 3909–15 |year= 1984 |pmid= 6328444 |doi=
*cite journal | author=Servillo L, Brewer HB, Osborne JC |title=Evaluation of the mixed interaction between apolipoproteins A-II and C-I equilibrium sedimentation. |journal=Biophys. Chem. |volume=13 |issue= 1 |pages= 29–38 |year= 1981 |pmid= 6789904 |doi=
*cite journal | author=Curry MD, McConathy WJ, Fesmire JD, Alaupovic P |title=Quantitative determination of apolipoproteins C-I and C-II in human plasma by separate electroimmunoassays. |journal=Clin. Chem. |volume=27 |issue= 4 |pages= 543–8 |year= 1981 |pmid= 7471419 |doi=
*cite journal | author=Rozek A, Buchko GW, Cushley RJ |title=Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy. |journal=Biochemistry |volume=34 |issue= 22 |pages= 7401–8 |year= 1995 |pmid= 7779782 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Trask B, Fertitta A, Christensen M, "et al." |title=Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. |journal=Genomics |volume=15 |issue= 1 |pages= 133–45 |year= 1993 |pmid= 8432525 |doi=
*cite journal | author=Kamino K, Yoshiiwa A, Nishiwaki Y, "et al." |title=Genetic association study between senile dementia of Alzheimer's type and APOE/C1/C2 gene cluster. |journal=Gerontology |volume=42 Suppl 1 |issue= |pages= 12–9 |year= 1996 |pmid= 8804993 |doi=
*cite journal | author=Rozek A, Buchko GW, Kanda P, Cushley RJ |title=Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy. |journal=Protein Sci. |volume=6 |issue= 9 |pages= 1858–68 |year= 1998 |pmid= 9300485 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Halushka MK, Fan JB, Bentley K, "et al." |title=Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 239–47 |year= 1999 |pmid= 10391210 |doi= 10.1038/10297
*cite journal | author=Freitas EM, Zhang WJ, Lalonde JP, "et al." |title=Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1. |journal=DNA Seq. |volume=9 |issue= 2 |pages= 89–100 |year= 1999 |pmid= 10520737 |doi=
*cite journal | author=Gautier T, Masson D, de Barros JP, "et al." |title=Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37504–9 |year= 2001 |pmid= 10978346 |doi= 10.1074/jbc. M007210200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using "in vitro" site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=

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