RACGAP1

Rac GTPase activating protein 1, also known as RACGAP1, is a human gene.

PBB_Summary
section_title =
summary_text = Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO (see MIM 165370), RAC (see RAC1; MIM 602048), and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases. [supplied by OMIM] cite web | title = Entrez Gene: RACGAP1 Rac GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29127| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Gerwins P, Blank JL, Johnson GL |title=Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8288–95 |year= 1997 |pmid= 9079650 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Nagata K, Puls A, Futter C, "et al." |title=The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. |journal=EMBO J. |volume=17 |issue= 1 |pages= 149–58 |year= 1998 |pmid= 9427749 |doi= 10.1093/emboj/17.1.149
*cite journal | author=Tapon N, Nagata K, Lamarche N, Hall A |title=A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1395–404 |year= 1998 |pmid= 9482736 |doi= 10.1093/emboj/17.5.1395
*cite journal | author=Touré A, Dorseuil O, Morin L, "et al." |title=MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. |journal=J. Biol. Chem. |volume=273 |issue= 11 |pages= 6019–23 |year= 1998 |pmid= 9497316 |doi=
*cite journal | author=Abo A, Qu J, Cammarano MS, "et al." |title=PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. |journal=EMBO J. |volume=17 |issue= 22 |pages= 6527–40 |year= 1999 |pmid= 9822598 |doi= 10.1093/emboj/17.22.6527
*cite journal | author=Zuber J, Tchernitsa OI, Hinzmann B, "et al." |title=A genome-wide survey of RAS transformation targets. |journal=Nat. Genet. |volume=24 |issue= 2 |pages= 144–52 |year= 2000 |pmid= 10655059 |doi= 10.1038/72799
*cite journal | author=Das B, Shu X, Day GJ, "et al." |title=Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15074–81 |year= 2000 |pmid= 10748082 |doi= 10.1074/jbc.M907269199
*cite journal | author=Nagase T, Kikuno R, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=
*cite journal | author=Kawashima T, Hirose K, Satoh T, "et al." |title=MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. |journal=Blood |volume=96 |issue= 6 |pages= 2116–24 |year= 2000 |pmid= 10979956 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Hirose K, Kawashima T, Iwamoto I, "et al." |title=MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5821–8 |year= 2001 |pmid= 11085985 |doi= 10.1074/jbc.M007252200
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Caloca MJ, Wang H, Delemos A, "et al." |title=Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 18303–12 |year= 2001 |pmid= 11278894 |doi= 10.1074/jbc.M011368200
*cite journal | author=Toure A, Morin L, Pineau C, "et al." |title=Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20309–15 |year= 2001 |pmid= 11278976 |doi= 10.1074/jbc.M011740200
*cite journal | author=Mishima M, Kaitna S, Glotzer M |title=Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. |journal=Dev. Cell |volume=2 |issue= 1 |pages= 41–54 |year= 2002 |pmid= 11782313 |doi=
*cite journal | author=Vikis HG, Li W, Guan KL |title=The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. |journal=Genes Dev. |volume=16 |issue= 7 |pages= 836–45 |year= 2002 |pmid= 11937491 |doi= 10.1101/gad.966402
*cite journal | author=Kitamura T, Kawashima T, Minoshima Y, "et al." |title=Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation. |journal=Cell Struct. Funct. |volume=26 |issue= 6 |pages= 645–51 |year= 2002 |pmid= 11942621 |doi=
*cite journal | author=Côté JF, Vuori K |title=Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. |journal=J. Cell. Sci. |volume=115 |issue= Pt 24 |pages= 4901–13 |year= 2003 |pmid= 12432077 |doi=

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