SKP1A

S-phase kinase-associated protein 1A (p19A), also known as SKP1A, is a human gene.cite web | title = Entrez Gene: SKP1A S-phase kinase-associated protein 1A (p19A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6500| accessdate = ]

This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to proteins containing an F-box motif, such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysiscite journal|journal=Cell|title=SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.|author= Bai et al.|date=1996|volume=86|issue=2|pages=263–74|doi=10.1016/S0092-8674(00)80098-7] . The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhang H, Kobayashi R, Galaktionov K, Beach D |title=p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. |journal=Cell |volume=82 |issue= 6 |pages= 915–25 |year= 1995 |pmid= 7553852 |doi=
*cite journal | author=Chen H, Thalmann I, Adams JC, "et al." |title=cDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs. |journal=Genomics |volume=27 |issue= 3 |pages= 389–98 |year= 1995 |pmid= 7558018 |doi= 10.1006/geno.1995.1068
*cite journal | author=Sowden J, Morrison K, Schofield J, "et al." |title=A novel cDNA with homology to an RNA polymerase II elongation factor maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l). |journal=Genomics |volume=29 |issue= 1 |pages= 145–51 |year= 1996 |pmid= 8530064 |doi= 10.1006/geno.1995.1225
*cite journal | author=Demetrick DJ, Zhang H, Beach DH |title=Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 104–7 |year= 1996 |pmid= 8646875 |doi=
*cite journal | author=Bai C, Sen P, Hofmann K, "et al." |title=SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. |journal=Cell |volume=86 |issue= 2 |pages= 263–74 |year= 1996 |pmid= 8706131 |doi=
*cite journal | author=Brown KA, Leek JP, Lench NJ, "et al." |title=Human sequences homologous to the gene for the cochlear protein Ocp-II do not map to currently known non-syndromic hearing loss loci. |journal=Ann. Hum. Genet. |volume=60 |issue= Pt 5 |pages= 385–9 |year= 1996 |pmid= 8912791 |doi=
*cite journal | author=Liang Y, Chen H, Asher JH, "et al." |title=Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13-12qter. |journal=Gene |volume=184 |issue= 2 |pages= 163–7 |year= 1997 |pmid= 9031623 |doi=
*cite journal | author=Lisztwan J, Marti A, Sutterlüty H, "et al." |title=Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. |journal=EMBO J. |volume=17 |issue= 2 |pages= 368–83 |year= 1998 |pmid= 9430629 |doi= 10.1093/emboj/17.2.368
*cite journal | author=Ng RW, Arooz T, Yam CH, "et al." |title=Characterization of the cullin and F-box protein partner Skp1. |journal=FEBS Lett. |volume=438 |issue= 3 |pages= 183–9 |year= 1998 |pmid= 9827542 |doi=
*cite journal | author=Yam CH, Ng RW, Siu WY, "et al." |title=Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 635–45 |year= 1999 |pmid= 9858587 |doi=
*cite journal | author=Henzl MT, Thalmann I, Thalmann R |title=OCP2 exists as a dimer in the organ of Corti. |journal=Hear. Res. |volume=126 |issue= 1-2 |pages= 37–46 |year= 1999 |pmid= 9872132 |doi=
*cite journal | author=Winston JT, Strack P, Beer-Romero P, "et al." |title=The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. |journal=Genes Dev. |volume=13 |issue= 3 |pages= 270–83 |year= 1999 |pmid= 9990852 |doi=
*cite journal | author=Ilyin GP, Rialland M, Glaise D, Guguen-Guillouzo C |title=Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. |journal=FEBS Lett. |volume=459 |issue= 1 |pages= 75–9 |year= 1999 |pmid= 10508920 |doi=
*cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, "et al." |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177–9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2
*cite journal | author=Winston JT, Koepp DM, Zhu C, "et al." |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4
*cite journal | author=Suzuki H, Chiba T, Suzuki T, "et al." |title=Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2877–84 |year= 2000 |pmid= 10644755 |doi=
*cite journal | author=Read MA, Brownell JE, Gladysheva TB, "et al." |title=Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2326–33 |year= 2000 |pmid= 10713156 |doi=
*cite journal | author=Schulman BA, Carrano AC, Jeffrey PD, "et al." |title=Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. |journal=Nature |volume=408 |issue= 6810 |pages= 381–6 |year= 2000 |pmid= 11099048 |doi= 10.1038/35042620
*cite journal | author=Lyapina S, Cope G, Shevchenko A, "et al." |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382–5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780
*cite journal | author=Fukuchi M, Imamura T, Chiba T, "et al." |title=Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. |journal=Mol. Biol. Cell |volume=12 |issue= 5 |pages= 1431–43 |year= 2001 |pmid= 11359933 |doi=

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