RANBP5

RAN binding protein 5, also known as RANBP5, is a human gene.

PBB_Summary
section_title =
summary_text = Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.cite web | title = Entrez Gene: RANBP5 RAN binding protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3843| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: in search of a leader. |journal=Front. Biosci. |volume=2 |issue= |pages= d578–87 |year= 2004 |pmid= 9366553 |doi=
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138–43 |year= 1998 |pmid= 9562972 |doi=
*cite journal | author=Christophe D, Christophe-Hobertus C, Pichon B |title=Nuclear targeting of proteins: how many different signals? |journal=Cell. Signal. |volume=12 |issue= 5 |pages= 337–41 |year= 2000 |pmid= 10822175 |doi=
*cite journal | author=Chook YM, Blobel G |title=Karyopherins and nuclear import. |journal=Curr. Opin. Struct. Biol. |volume=11 |issue= 6 |pages= 703–15 |year= 2002 |pmid= 11751052 |doi=
*cite journal | author=Bukrinsky MI, Sharova N, Dempsey MP, "et al." |title=Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 14 |pages= 6580–4 |year= 1992 |pmid= 1631159 |doi=
*cite journal | author=Bukrinsky MI, Haggerty S, Dempsey MP, "et al." |title=A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. |journal=Nature |volume=365 |issue= 6447 |pages= 666–9 |year= 1993 |pmid= 8105392 |doi= 10.1038/365666a0
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Yaseen NR, Blobel G |title=Cloning and characterization of human karyopherin beta3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4451–6 |year= 1997 |pmid= 9114010 |doi=
*cite journal | author=Deane R, Schäfer W, Zimmermann HP, "et al." |title=Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1. |journal=Mol. Cell. Biol. |volume=17 |issue= 9 |pages= 5087–96 |year= 1997 |pmid= 9271386 |doi=
*cite journal | author=Gallay P, Hope T, Chin D, Trono D |title=HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9825–30 |year= 1997 |pmid= 9275210 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Henderson BR, Percipalle P |title=Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta. |journal=J. Mol. Biol. |volume=274 |issue= 5 |pages= 693–707 |year= 1998 |pmid= 9405152 |doi= 10.1006/jmbi.1997.1420
*cite journal | author=Efthymiadis A, Briggs LJ, Jans DA |title=The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1623–8 |year= 1998 |pmid= 9430704 |doi=
*cite journal | author=Vodicka MA, Koepp DM, Silver PA, Emerman M |title=HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. |journal=Genes Dev. |volume=12 |issue= 2 |pages= 175–85 |year= 1998 |pmid= 9436978 |doi=
*cite journal | author=Popov S, Rexach M, Zybarth G, "et al." |title=Viral protein R regulates nuclear import of the HIV-1 pre-integration complex. |journal=EMBO J. |volume=17 |issue= 4 |pages= 909–17 |year= 1998 |pmid= 9463369 |doi= 10.1093/emboj/17.4.909
*cite journal | author=Popov S, Rexach M, Ratner L, "et al." |title=Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 13347–52 |year= 1998 |pmid= 9582382 |doi=
*cite journal | author=Fouchier RA, Meyer BE, Simon JH, "et al." |title=Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex. |journal=J. Virol. |volume=72 |issue= 7 |pages= 6004–13 |year= 1998 |pmid= 9621063 |doi=

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