GAB1

GRB2-associated binding protein 1, also known as GAB1, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: GAB1 GRB2-associated binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2549| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Holgado-Madruga M, Emlet DR, Moscatello DK, "et al." |title=A Grb2-associated docking protein in EGF- and insulin-receptor signalling. |journal=Nature |volume=379 |issue= 6565 |pages= 560–4 |year= 1996 |pmid= 8596638 |doi= 10.1038/379560a0
*cite journal | author=Fixman ED, Holgado-Madruga M, Nguyen L, "et al." |title=Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 20167–72 |year= 1997 |pmid= 9242692 |doi=
*cite journal | author=Nguyen L, Holgado-Madruga M, Maroun C, "et al." |title=Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356. |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20811–9 |year= 1997 |pmid= 9252406 |doi=
*cite journal | author=Holgado-Madruga M, Moscatello DK, Emlet DR, "et al." |title=Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 23 |pages= 12419–24 |year= 1997 |pmid= 9356464 |doi=
*cite journal | author=Rocchi S, Tartare-Deckert S, Murdaca J, "et al." |title=Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules. |journal=Mol. Endocrinol. |volume=12 |issue= 7 |pages= 914–23 |year= 1998 |pmid= 9658397 |doi=
*cite journal | author=Qiu M, Hua S, Agrawal M, "et al." |title=Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 443–7 |year= 1999 |pmid= 9878555 |doi= 10.1006/bbrc.1998.9795
*cite journal | author=Lehr S, Kotzka J, Herkner A, "et al." |title=Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro. |journal=Biochemistry |volume=38 |issue= 1 |pages= 151–9 |year= 1999 |pmid= 9890893 |doi= 10.1021/bi9818265
*cite journal | author=Maroun CR, Holgado-Madruga M, Royal I, "et al." |title=The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1784–99 |year= 1999 |pmid= 10022866 |doi=
*cite journal | author=Nishida K, Yoshida Y, Itoh M, "et al." |title=Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. |journal=Blood |volume=93 |issue= 6 |pages= 1809–16 |year= 1999 |pmid= 10068651 |doi=
*cite journal | author=Gual P, Giordano S, Williams TA, "et al." |title=Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis. |journal=Oncogene |volume=19 |issue= 12 |pages= 1509–18 |year= 2000 |pmid= 10734310 |doi= 10.1038/sj.onc.1203514
*cite journal | author=Braun L, Ghebrehiwet B, Cossart P |title=gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes. |journal=EMBO J. |volume=19 |issue= 7 |pages= 1458–66 |year= 2000 |pmid= 10747014 |doi= 10.1093/emboj/19.7.1458
*cite journal | author=Sakkab D, Lewitzky M, Posern G, "et al." |title=Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 10772–8 |year= 2000 |pmid= 10753869 |doi=
*cite journal | author=Lehr S, Kotzka J, Herkner A, "et al." |title=Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro. |journal=Biochemistry |volume=39 |issue= 35 |pages= 10898–907 |year= 2000 |pmid= 10978177 |doi=
*cite journal | author=Sachs M, Brohmann H, Zechner D, "et al." |title=Essential role of Gab1 for signaling by the c-Met receptor in vivo. |journal=J. Cell Biol. |volume=150 |issue= 6 |pages= 1375–84 |year= 2000 |pmid= 10995442 |doi=
*cite journal | author=Yart A, Laffargue M, Mayeux P, "et al." |title=A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8856–64 |year= 2001 |pmid= 11134009 |doi= 10.1074/jbc.M006966200
*cite journal | author=Ingham RJ, Santos L, Dang-Lawson M, "et al." |title=The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 12257–65 |year= 2001 |pmid= 11278704 |doi= 10.1074/jbc.M010590200
*cite journal | author=Lewitzky M, Kardinal C, Gehring NH, "et al." |title=The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif. |journal=Oncogene |volume=20 |issue= 9 |pages= 1052–62 |year= 2001 |pmid= 11314042 |doi= 10.1038/sj.onc.1204202
*cite journal | author=Cunnick JM, Mei L, Doupnik CA, Wu J |title=Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24380–7 |year= 2001 |pmid= 11323411 |doi= 10.1074/jbc.M010275200
*cite journal | author=Kurokawa K, Iwashita T, Murakami H, "et al." |title=Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction. |journal=Oncogene |volume=20 |issue= 16 |pages= 1929–38 |year= 2001 |pmid= 11360177 |doi= 10.1038/sj.onc.1204290
*cite journal | author=Kameda H, Risinger JI, Han BB, "et al." |title=Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression. |journal=Cell Growth Differ. |volume=12 |issue= 6 |pages= 307–18 |year= 2001 |pmid= 11432805 |doi=

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