JUP

Junction plakoglobin, also known as JUP, is a human gene.

PBB_Summary
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summary_text = This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [cite web | title = Entrez Gene: JUP junction plakoglobin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3728| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Beavon IR |title=The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation. |journal=Eur. J. Cancer |volume=36 |issue= 13 Spec No |pages= 1607–20 |year= 2000 |pmid= 10959047 |doi=
*cite journal | author=Wilson PD |title=Polycystin: new aspects of structure, function, and regulation. |journal=J. Am. Soc. Nephrol. |volume=12 |issue= 4 |pages= 834–45 |year= 2001 |pmid= 11274246 |doi=
*cite journal | author=Protonotarios NI, Tsatsopoulou AA, Gatzoulis KA |title=Arrhythmogenic right ventricular cardiomyopathy caused by a deletion in plakoglobin (Naxos disease). |journal=Cardiac electrophysiology review |volume=6 |issue= 1-2 |pages= 72–80 |year= 2002 |pmid= 11984022 |doi=
*cite journal | author=Knudsen KA, Wheelock MJ |title=Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. |journal=J. Cell Biol. |volume=118 |issue= 3 |pages= 671–9 |year= 1992 |pmid= 1639850 |doi=
*cite journal | author=Arnemann J, Spurr NK, Wheeler GN, "et al." |title=Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP). |journal=Genomics |volume=10 |issue= 3 |pages= 640–5 |year= 1991 |pmid= 1889810 |doi=
*cite journal | author=Franke WW, Goldschmidt MD, Zimbelmann R, "et al." |title=Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 11 |pages= 4027–31 |year= 1989 |pmid= 2726765 |doi=
*cite journal | author=Kinch MS, Clark GJ, Der CJ, Burridge K |title=Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. |journal=J. Cell Biol. |volume=130 |issue= 2 |pages= 461–71 |year= 1995 |pmid= 7542250 |doi=
*cite journal | author=Aberle H, Bierkamp C, Torchard D, "et al." |title=The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 14 |pages= 6384–8 |year= 1995 |pmid= 7604000 |doi=
*cite journal | author=Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR |title=Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 20201–6 |year= 1995 |pmid= 7650039 |doi=
*cite journal | author=Daniel JM, Reynolds AB |title=The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 4819–24 |year= 1995 |pmid= 7651399 |doi=
*cite journal | author=Kanai Y, Ochiai A, Shibata T, "et al." |title=c-erbB-2 gene product directly associates with beta-catenin and plakoglobin. |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 3 |pages= 1067–72 |year= 1995 |pmid= 7702605 |doi= 10.1006/bbrc.1995.1443
*cite journal | author=Roh JY, Stanley JR |title=Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment. |journal=J. Invest. Dermatol. |volume=104 |issue= 5 |pages= 720–4 |year= 1995 |pmid= 7738346 |doi=
*cite journal | author=Shibamoto S, Hayakawa M, Takeuchi K, "et al." |title=Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. |journal=J. Cell Biol. |volume=128 |issue= 5 |pages= 949–57 |year= 1995 |pmid= 7876318 |doi=
*cite journal | author=Rubinfeld B, Souza B, Albert I, "et al." |title=The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. |journal=J. Biol. Chem. |volume=270 |issue= 10 |pages= 5549–55 |year= 1995 |pmid= 7890674 |doi=
*cite journal | author=Troyanovsky SM, Troyanovsky RB, Eshkind LG, "et al." |title=Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 10790–4 |year= 1994 |pmid= 7971964 |doi=
*cite journal | author=Shibata T, Gotoh M, Ochiai A, Hirohashi S |title=Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 1 |pages= 519–22 |year= 1994 |pmid= 8074697 |doi= 10.1006/bbrc.1994.2213
*cite journal | author=Hinck L, Näthke IS, Papkoff J, Nelson WJ |title=Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. |journal=J. Cell Biol. |volume=125 |issue= 6 |pages= 1327–40 |year= 1994 |pmid= 8207061 |doi=
*cite journal | author=Arnemann J, Sullivan KH, Magee AI, "et al." |title=Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis. |journal=J. Cell. Sci. |volume=104 ( Pt 3) |issue= |pages= 741–50 |year= 1993 |pmid= 8314871 |doi=
*cite journal | author=Ozawa M, Nuruki K, Toyoyama H, Ohi Y |title=Cloning of an alternative form of plakoglobin (gamma-catenin) lacking the fourth armadillo repeat. |journal=J. Biochem. |volume=118 |issue= 4 |pages= 836–40 |year= 1996 |pmid= 8576101 |doi=
*cite journal | author=Fuchs M, Müller T, Lerch MM, Ullrich A |title=Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. |journal=J. Biol. Chem. |volume=271 |issue= 28 |pages= 16712–9 |year= 1996 |pmid= 8663237 |doi=

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