APOA5

Apolipoprotein A-V, also known as APOA5, is a human gene.cite web | title = Entrez Gene: APOA5 apolipoprotein A-V| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116519| accessdate = ]

The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors.cite journal | author = Nilsson SK, Christensen S, Raarup MK, Ryan RO, Nielsen MS, Olivecrona G | title = Endocytosis of apolipoprotein AV by members of the low density lipoprotein receptor and the Vps10p domain receptor families | journal = J. Biol. Chem. | volume = | issue = | pages = | year = 2008 | month = July | pmid = 18603531 | doi = 10.1074/jbc.M802721200 | url = | issn = ]

This gene uses alternate polyadenylation sites and is located proximal to the apolipoprotein gene cluster on chromosome 11q23.

ee also

* Apolipoprotein

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pennacchio LA, Rubin EM |title=Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 4 |pages= 529–34 |year= 2004 |pmid= 12615678 |doi= 10.1161/01.ATV.0000054194.78240.45
*cite journal | author=Jakel H, Nowak M, Helleboid-Chapman A, "et al." |title=Is apolipoprotein A5 a novel regulator of triglyceride-rich lipoproteins? |journal=Ann. Med. |volume=38 |issue= 1 |pages= 2–10 |year= 2006 |pmid= 16448983 |doi= 10.1080/07853890500407488
*cite journal | author=Calandra S, Priore Oliva C, Tarugi P, Bertolini S |title=APOA5 and triglyceride metabolism, lesson from human APOA5 deficiency. |journal=Curr. Opin. Lipidol. |volume=17 |issue= 2 |pages= 122–7 |year= 2007 |pmid= 16531747 |doi= 10.1097/01.mol.0000217892.00618.54
*cite journal | author=Wong K, Ryan RO |title=Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. |journal=Curr. Opin. Lipidol. |volume=18 |issue= 3 |pages= 319–24 |year= 2007 |pmid= 17495607 |doi= 10.1097/MOL.0b013e328133856c
*cite journal | author=van der Vliet HN, Sammels MG, Leegwater AC, "et al." |title=Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44512–20 |year= 2002 |pmid= 11577099 |doi= 10.1074/jbc.M106888200
*cite journal | author=Pennacchio LA, Olivier M, Hubacek JA, "et al." |title=An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. |journal=Science |volume=294 |issue= 5540 |pages= 169–73 |year= 2001 |pmid= 11588264 |doi= 10.1126/science.1064852
*cite journal | author=Nabika T, Nasreen S, Kobayashi S, Masuda J |title=The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese. |journal=Atherosclerosis |volume=165 |issue= 2 |pages= 201–4 |year= 2003 |pmid= 12417270 |doi=
*cite journal | author=Pennacchio LA, Olivier M, Hubacek JA, "et al." |title=Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. |journal=Hum. Mol. Genet. |volume=11 |issue= 24 |pages= 3031–8 |year= 2003 |pmid= 12417524 |doi=
*cite journal | author=Talmud PJ, Hawe E, Martin S, "et al." |title=Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. |journal=Hum. Mol. Genet. |volume=11 |issue= 24 |pages= 3039–46 |year= 2003 |pmid= 12417525 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vu-Dac N, Gervois P, Jakel H, "et al." |title=Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17982–5 |year= 2003 |pmid= 12637506 |doi= 10.1074/jbc.M212191200
*cite journal | author=Prieur X, Coste H, Rodriguez JC |title=The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25468–80 |year= 2003 |pmid= 12709436 |doi= 10.1074/jbc.M301302200
*cite journal | author=Weinberg RB, Cook VR, Beckstead JA, "et al." |title=Structure and interfacial properties of human apolipoprotein A-V. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34438–44 |year= 2003 |pmid= 12810715 |doi= 10.1074/jbc.M303784200
*cite journal | author=Horínek A, Vráblík M, Ceska R, "et al." |title=T-1131-->C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals. |journal=Atherosclerosis |volume=167 |issue= 2 |pages= 369–70 |year= 2003 |pmid= 12818421 |doi=
*cite journal | author=Beckstead JA, Oda MN, Martin DD, "et al." |title=Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis. |journal=Biochemistry |volume=42 |issue= 31 |pages= 9416–23 |year= 2003 |pmid= 12899628 |doi= 10.1021/bi034509t
*cite journal | author=Kao JT, Wen HC, Chien KL, "et al." |title=A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia. |journal=Hum. Mol. Genet. |volume=12 |issue= 19 |pages= 2533–9 |year= 2004 |pmid= 12915450 |doi= 10.1093/hmg/ddg255
*cite journal | author=Vrablík M, Horínek A, Ceska R, "et al." |title=Ser19-->Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic people. |journal=J. Med. Genet. |volume=40 |issue= 8 |pages= e105 |year= 2003 |pmid= 12920097 |doi=
*cite journal | author=Lai CQ, Tai ES, Tan CE, "et al." |title=The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore. |journal=J. Lipid Res. |volume=44 |issue= 12 |pages= 2365–73 |year= 2004 |pmid= 12951359 |doi= 10.1194/jlr.M300251-JLR200
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes