HNRPA1

Heterogeneous nuclear ribonucleoprotein A1, also known as HNRPA1, is a human gene.

PBB_Summary
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summary_text = This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [cite web | title = Entrez Gene: HNRPA1 heterogeneous nuclear ribonucleoprotein A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3178| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kim S, Park GH, Paik WK |title=Recent advances in protein methylation: enzymatic methylation of nucleic acid binding proteins. |journal=Amino Acids |volume=15 |issue= 4 |pages= 291–306 |year= 1999 |pmid= 9891755 |doi=
*cite journal | author=Buvoli M, Cobianchi F, Bestagno MG, "et al." |title=Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein. |journal=EMBO J. |volume=9 |issue= 4 |pages= 1229–35 |year= 1990 |pmid= 1691095 |doi=
*cite journal | author=Saccone S, Biamonti G, Maugeri S, "et al." |title=Assignment of the human heterogeneous nuclear ribonucleoprotein A1 gene (HNRPA1) to chromosome 12q13.1 by cDNA competitive in situ hybridization. |journal=Genomics |volume=12 |issue= 1 |pages= 171–4 |year= 1992 |pmid= 1733858 |doi=
*cite journal | author=Ghetti A, Bolognesi M, Cobianchi F, Morandi C |title=Modeling by homology of RNA binding domain in A1 hnRNP protein. |journal=FEBS Lett. |volume=277 |issue= 1-2 |pages= 272–6 |year= 1991 |pmid= 2176620 |doi=
*cite journal | author=Biamonti G, Buvoli M, Bassi MT, "et al." |title=Isolation of an active gene encoding human hnRNP protein A1. Evidence for alternative splicing. |journal=J. Mol. Biol. |volume=207 |issue= 3 |pages= 491–503 |year= 1989 |pmid= 2760922 |doi=
*cite journal | author=Buvoli M, Biamonti G, Tsoulfas P, "et al." |title=cDNA cloning of human hnRNP protein A1 reveals the existence of multiple mRNA isoforms. |journal=Nucleic Acids Res. |volume=16 |issue= 9 |pages= 3751–70 |year= 1988 |pmid= 2836799 |doi=
*cite journal | author=Riva S, Morandi C, Tsoulfas P, "et al." |title=Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1. |journal=EMBO J. |volume=5 |issue= 9 |pages= 2267–73 |year= 1986 |pmid= 3023065 |doi=
*cite journal | author=Epplen C, Epplen JT |title=Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes. |journal=Hum. Genet. |volume=93 |issue= 1 |pages= 35–41 |year= 1994 |pmid= 7505766 |doi=
*cite journal | author=Siomi H, Dreyfuss G |title=A nuclear localization domain in the hnRNP A1 protein. |journal=J. Cell Biol. |volume=129 |issue= 3 |pages= 551–60 |year= 1995 |pmid= 7730395 |doi=
*cite journal | author=Weighardt F, Biamonti G, Riva S |title=Nucleo-cytoplasmic distribution of human hnRNP proteins: a search for the targeting domains in hnRNP A1. |journal=J. Cell. Sci. |volume=108 ( Pt 2) |issue= |pages= 545–55 |year= 1995 |pmid= 7769000 |doi=
*cite journal | author=Rajpurohit R, Lee SO, Park JO, "et al." |title=Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1075–82 |year= 1994 |pmid= 8288564 |doi=
*cite journal | author=Hamilton BJ, Nagy E, Malter JS, "et al." |title=Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences. |journal=J. Biol. Chem. |volume=268 |issue= 12 |pages= 8881–7 |year= 1993 |pmid= 8473331 |doi=
*cite journal | author=Michael WM, Choi M, Dreyfuss G |title=A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. |journal=Cell |volume=83 |issue= 3 |pages= 415–22 |year= 1996 |pmid= 8521471 |doi=
*cite journal | author=Black AC, Luo J, Chun S, "et al." |title=Specific binding of polypyrimidine tract binding protein and hnRNP A1 to HIV-1 CRS elements. |journal=Virus Genes |volume=12 |issue= 3 |pages= 275–85 |year= 1997 |pmid= 8883365 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Xu RM, Jokhan L, Cheng X, "et al." |title=Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. |journal=Structure |volume=5 |issue= 4 |pages= 559–70 |year= 1997 |pmid= 9115444 |doi=
*cite journal | author=Bonifaci N, Moroianu J, Radu A, Blobel G |title=Karyopherin beta2 mediates nuclear import of a mRNA binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 5055–60 |year= 1997 |pmid= 9144189 |doi=
*cite journal | author=Shamoo Y, Krueger U, Rice LM, "et al." |title=Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution. |journal=Nat. Struct. Biol. |volume=4 |issue= 3 |pages= 215–22 |year= 1997 |pmid= 9164463 |doi=
*cite journal | author=Neubauer G, King A, Rappsilber J, "et al." |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700

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