Psychotomimesis

Psychotomimesis can be defined as the onset of psychotic symptoms following the administration of a drug. Particularly, mixed kappa receptor agonist mu antagonist opioid analgesics can cause dose-related psychotomimesis. [Science [0036-8075] Psychotomimesis mediated by kappa opiate receptors Pfeiffer yr:1986 vol:233 iss:4765 pg:774 -6] This adverse effect, incidence 1-2%, limits their use. Pentazocine and Butorphanol fall under this opioid class.

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