Growth hormone 1

Growth hormone 1

Growth hormone 1, also known as GH1, is a human gene.

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summary_text = The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [cite web | title = Entrez Gene: GH1 growth hormone 1| url =| accessdate = ]

ee also

* Growth hormone


Further reading

citations =
*cite journal | author=Binder G |title=Isolated growth hormone deficiency and the GH-1 gene: update 2002. |journal=Horm. Res. |volume=58 Suppl 3 |issue= |pages= 2–6 |year= 2003 |pmid= 12435888 |doi=
*cite journal | author=Waxman DJ, O'Connor C |title=Growth hormone regulation of sex-dependent liver gene expression. |journal=Mol. Endocrinol. |volume=20 |issue= 11 |pages= 2613–29 |year= 2007 |pmid= 16543404 |doi= 10.1210/me.2006-0007
*cite journal | author=Cattini PA, Yang X, Jin Y, Detillieux KA |title=Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression. |journal=Neuroendocrinology |volume=83 |issue= 3-4 |pages= 145–53 |year= 2006 |pmid= 17047377 |doi= 10.1159/000095522
*cite journal | author=Wagner K, Hemminki K, Försti A |title=The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development. |journal=Breast Cancer Res. Treat. |volume=104 |issue= 3 |pages= 233–48 |year= 2007 |pmid= 17082888 |doi= 10.1007/s10549-006-9411-9

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  • growth hormone — any substance that stimulates or controls the growth of an organism, esp. a species specific hormone, as the human hormone somatotropin, secreted by the anterior pituitary gland. Abbr.: GH [1920 25] * * * also called  somatotropin , or  human… …   Universalium

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