- FGG
Fibrinogen gamma chain, also known as FGG, is a human
gene .PBB_Summary
section_title =
summary_text = The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [cite web | title = Entrez Gene: FGG fibrinogen gamma chain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2266| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Doolittle RF |title=Fibrinogen and fibrin. |journal=Annu. Rev. Biochem. |volume=53 |issue= |pages= 195–229 |year= 1984 |pmid= 6383194 |doi= 10.1146/annurev.bi.53.070184.001211
*cite journal | author=Herrick S, Blanc-Brude O, Gray A, Laurent G |title=Fibrinogen. |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 7 |pages= 741–6 |year= 1999 |pmid= 10467729 |doi=
*cite journal | author=Everse SJ |title=New insights into fibrin (ogen) structure and function. |journal=Vox Sang. |volume=83 Suppl 1 |issue= |pages= 375–82 |year= 2003 |pmid= 12617173 |doi=
*cite journal | author=Mosesson MW |title=Fibrinogen gamma chain functions. |journal=J. Thromb. Haemost. |volume=1 |issue= 2 |pages= 231–8 |year= 2003 |pmid= 12871494 |doi=
*cite journal | author=Scott EM, Ariëns RA, Grant PJ |title=Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 9 |pages= 1558–66 |year= 2005 |pmid= 15217804 |doi= 10.1161/01.ATV.0000136649.83297.bfPBB_Controls
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