- XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa), also known as XRCC6, is a human
gene .PBB_Summary
section_title =
summary_text = The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [cite web | title = Entrez Gene: XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2547| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Smider V, Chu G |title=The end-joining reaction in V(D)J recombination. |journal=Semin. Immunol. |volume=9 |issue= 3 |pages= 189–97 |year= 1997 |pmid= 9200330 |doi= 10.1006/smim.1997.0070
*cite journal | author=Featherstone C, Jackson SP |title=Ku, a DNA repair protein with multiple cellular functions? |journal=Mutat. Res. |volume=434 |issue= 1 |pages= 3–15 |year= 1999 |pmid= 10377944 |doi=
*cite journal | author=Koike M |title=Dimerization, translocation and localization of Ku70 and Ku80 proteins. |journal=J. Radiat. Res. |volume=43 |issue= 3 |pages= 223–36 |year= 2003 |pmid= 12518983 |doi=PBB_Controls
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