- PLAU
Plasminogen activator, urokinase, also known as PLAU, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. [cite web | title = Entrez Gene: PLAU plasminogen activator, urokinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5328| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Ploug M, Gårdsvoll H, Jørgensen TJ, "et al." |title=Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy. |journal=Biochem. Soc. Trans. |volume=30 |issue= 2 |pages= 177–83 |year= 2002 |pmid= 12023847 |doi= 10.1042/
*cite journal | author=Alfano M, Sidenius N, Blasi F, Poli G |title=The role of urokinase-type plasminogen activator (uPA)/uPA receptor in HIV-1 infection. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 750–6 |year= 2004 |pmid= 12960238 |doi= 10.1189/jlb.0403176
*cite journal | author=Harbeck N, Kates RE, Gauger K, "et al." |title=Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer. |journal=Thromb. Haemost. |volume=91 |issue= 3 |pages= 450–6 |year= 2004 |pmid= 14983219 |doi= 10.1160/TH03-12-0798
*cite journal | author=Gilabert-Estelles J, Ramon LA, España F, "et al." |title=Expression of the fibrinolytic components in endometriosis. |journal=Pathophysiol. Haemost. Thromb. |volume=35 |issue= 1-2 |pages= 136–40 |year= 2006 |pmid= 16855359 |doi= 10.1159/000093556PBB_Controls
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