Chlordecone reductase

Chlordecone reductase
chlordecone reductase
Identifiers
EC number 1.1.1.225
CAS number 102484-73-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction

chlordecone alcohol + NADP+ \rightleftharpoons chlordecone + NADPH + H+

Thus, the two substrates of this enzyme are chlordecone alcohol and NADP+, whereas its 3 products are chlordecone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. This enzyme is also called CDR.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FVL.

References

  • Molowa DT, Shayne AG, Guzelian PS (1986). "Purification and characterization of chlordecone reductase from human liver". J. Biol. Chem. 261 (27): 12624–7. PMID 2427522. 
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