Transmethylation

Transmethylation

Transmethylation is a biologically important organic chemical reaction in which a methyl group is transferred from one compound to another.

An example of transmethylation is the recovery of methionine from homocysteine. In order to sustain sufficient reaction rates during metabolic stress, this reaction requires adequate levels of vitamin B12 and folic acid. Methyl tetrahydrofolate delivers methyl groups to form the active methyl form of vitamin B12 that is required for methylation of homocysteine. Deficiencies of vitamin B12 or folic acid cause increased levels of circulatiing homocysteine. Elevated homocysteine is a risk factor for cardiovascular disease and is linked to the metabolic syndrome (insulin insensitivity).


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  • transmethylation — permetilinimas statusas T sritis chemija apibrėžtis CH₃– grupės perkėlimas iš vieno junginio į kitą. atitikmenys: angl. transmethylation rus. переметилирование …   Chemijos terminų aiškinamasis žodynas

  • transmethylation — /trans meth euh lay sheuhn, tranz /, n. Chem. the transfer of a methyl group from one compound to another. [TRANS + METHYLATION] * * * …   Universalium

  • transmethylation — noun The transfer of a methyl group between molecules, especially between biological compounds such as amino acids or the components of nucleic acids …   Wiktionary

  • transmethylation — Transfer of a methyl group from one compound to another; e.g., l homocysteine is converted to l methionine by the transfer to the latter of a methyl group. See methionine synthase. * * * trans·meth·yl·a·tion .meth ə lā shən n a chemical reaction… …   Medical dictionary

  • transmethylation — n. transferring of one methyl group from one compound to another (Chemistry) …   English contemporary dictionary

  • transmethylation — trans·methylation …   English syllables

  • transmethylation — n. the process whereby an amino acid donates its terminal methyl ( CH3) group for the methylation of other compounds. Methionine is the principal methyl donor in the body and the donated methyl group may subsequently be involved in the synthesis… …   The new mediacal dictionary

  • transmethylation — |tran(t)s, raan , nz+ noun Etymology: trans + methylation : a chemical reaction in which a methyl group is transferred from one compound to another …   Useful english dictionary

  • Трансметилирование (Transmethylation) — реакция, характеризующаяся потерей аминокислотой своей конечной метиловой (СНЗ) группы, которая присоединяется к другим соединениям. Основным донором метиловой группы является мстионин; в дальнейшем эта группа может принимать участие в процессе… …   Медицинские термины

  • ТРАНСМЕТИЛИРОВАНИЕ — (transmethylation) реакция, характеризующаяся потерей аминокислотой своей конечной метиловой (СНЗ) группы, которая присоединяется к другим соединениям. Основным донором метиловой группы является мстионин; в дальнейшем эта группа может принимать… …   Толковый словарь по медицине

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