Neurofuran

Neurofuran

Neurofurans are 22-carbon compounds formed nonenzymatically by free radical mediated peroxidation of docosahexaenoic acid (DHA), an ω-3 essential fatty acid. The neurofurans are similar to the isofurans and are formed under similar conditions of oxidative stress, containing a substituted tetrahydrofuran ring. Measurement of the neurofurans may ultimately prove useful in diagnosis, timing and selection of dose in the treatment and chemoprevention of neurodegenerative disease. [1]


References

  1. ^ Song WL, Lawson JA, Reilly D, Rokach J, Chang CT, Giasson B, and FitzGerald GA. (2007). "Neurofurans: Novel indices of oxidant stress derived from docosahexaenoic acid". J Biol Chem 283 (1): 6. doi:10.1074/jbc.M706124200. PMID 17921521. 

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  • neurofuran — noun Any of various 22 carbon compounds, similar to the isofurans, formed nonenzymatically by free radical mediated peroxidation of docosahexaenoic acid …   Wiktionary

  • Essential fatty acid — Essential fatty acids, or EFAs, are fatty acids that cannot be constructed within an organism from other components (generally all references are to humans) by any known chemical pathways; and therefore mustbe obtained from the diet. The term… …   Wikipedia

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