Small nucleolar RNA SNORD88

Small Nucleolar RNA SNORD88 (also known as HBII-180) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNORD88 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs cite journal |author= Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I; |title= Purified box C/D snoRNPs are able to reproduce site-specific2'-O-methylation of target RNA in vitro. |journal= Mol Cell Biol |volume= 22 |issue= |pages= 6663–6668 |year= 2002 |pmid=12215523 |doi= 10.1128/MCB.22.19.6663-6668.2002 ] . This snoRNA is the human orthologue of mouse snoRNA MBII-180 cite journal |author= Huttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H,Bachellerie JP, Brosius J; |title= RNomics: an experimental approach that identifies 201 candidates fornovel, small, non-messenger RNAs in mouse. |journal= EMBO J |volume= 20 |issue= |pages= 2943–2953 |year= 2001 |pmid=11387227 |doi= 10.1093/emboj/20.11.2943] . SNORD88 is also related to mouse snoRNA MBII-211. SNORD88 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residue C3680 cite journal |author= Lestrade L, Weber MJ; |title= snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs. |journal= Nucleic Acids Res |volume= 34 |issue= |pages= D158–D162 |year= 2006 |pmid=16381836 |doi= 10.1093/nar/gkj002] .

References

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=HBII-180 snoRNABase entry for SNORD88]