AG 489

Chembox new
ImageFile=Agatoxin-489.pngImageSize=350 px
IUPACName=N- [3- [3- [3- [4-(3-aminopropylamino) butylamino] propylamino] propyl-hydroxyamino] propyl] -2-(1H-indol-3-yl)acetamide
OtherNames=Agatoxin 489
Section1= Chembox Identifiers
CASNo=128549-96-2
PubChem=131007
SMILES=NCCCNCCCCNCCCNCCCN(O)CCCNC(Cc1c [nH] c2ccccc12)=O
Section2= Chembox Properties
Formula=C₂₆H₄₇N₇O₂
MolarMass=489.69708
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Section3= Chembox Hazards
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AG 489 (or agatoxin 489) is a component of the venom produced by Agelenopsis aperta.cite journal | author = Herold EE, Yaksh TL | title = Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat | journal = Anesthesiology | volume = 77 | issue = 3 | pages = 507–12 | year = 1992 | pmid = 1519789 | doi = | issn = ] It inhibits the ligand gated ion channel TRPV1 through a pore blocking mechanism.cite journal |author=Kitaguchi T, Swartz KJ |title=An inhibitor of TRPV1 channels isolated from funnel Web spider venom |journal=Biochemistry |volume=44 |issue=47 |pages=15544–9 |year=2005 |pmid=16300403 |doi=10.1021/bi051494l]

References

ee also

* Agatoxin

External links

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