RS 67333

Chembox new
Name = RS 67333
ImageFile = RS 67333.png ImageName = RS 67333
IUPACName =1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone
Section1 = Chembox Identifiers
CASNo = 160845-95-4
SMILES = C(CCC1CCN(CC1)CCCC)(=O)c1c(cc(c(c1)Cl)N)OC
Section2 = Chembox Properties
Formula = C₁₉H₂₉N₂O₂Cl
MolarMass = 352.9 g/mol

RS 67333 is a 5-HT₄ receptor partial agonist, being researched as a possible rapid acting antidepressantcite journal | author=Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. | title=Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action. | journal=Neuron. | year=2007 | pages=712–25 | volume=55 | issue=5 | pmid=17785179 | doi=10.1016/j.neuron.2007.07.041] , nootropiccite journal | author=Lamirault L, Simon H. | title=Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors. | journal=Neuropharmacology. | year=2001 | pages=844–53 | volume=41 | issue=7 | pmid=11684148 | doi=10.1016/S0028-3908(01)00123-X] , and treatment for Alzheimer'scite journal | author=Cho S, Hu Y. | title=Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. | journal=Experimental Neurology. | year=2007 | pages=274–8 | volume=203 | issue=1 | pmid=16978609 | doi=10.1016/j.expneurol.2006.07.021] .

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