HLA-A74

SerotypeA_normal
locus = A
type = 74
allelegroup = 74
broad = 19 | sister1 = 33 | sister2 = 32 | sister3 = 31 | sister4 = 30| sister5 = 29
alleles = 2
common_alleles = 1
rare_alleles = 1
alias =
nick1 = A74
allele1 = 01
allele2 = 03
rnick1 = A74.3
rallele1 = 03
mode = Subsaharan Africa
lead_comment = is a rare HLA-A allele group
types = 2
2ndType = 19
allele1 = 01 | type1alle1freq = 40 |type2alle1freq = 11 |N1 = 119
allele2 = 03 | type1alle2freq = 17 | N2 = 29
serotype_comment = has a poor serotyping rate

Disease associations

A significant association has been found between A74 and nasal polyposis.cite journal | author = Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D | title = HLA patterns in patients with nasal polyposis | journal = European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery | volume = 257 | issue = 3 | pages = 137–9 | year = 2000 | pmid = 10839486 | doi = ]

Allele distribution

AlleleFreq
Placement = right
Allele = A*7401
Freq1 = 11.6 | People1 = Colombia African Black
Freq2 = 9.4 | People2 = Kenya
Freq3 = 8.3 | People3 = Cameroon Beti
Freq4 = 7.7 | People4 = Guinea Bissau
Freq5 = 7.2 | People5 = Kenya Luo
Freq6 = 6.6 | People6 = Burkina Faso Mossi
Freq7 = 6.5 | People7 = South Africian Natal Zulu
Freq8 = 5.6 | People8 = Cape Verde Southeastern I…
Freq9 = 5.2 | People9 = Uganda Kampala
Freq10 = 5.0 | People10 = Cameroon Yaounde
Freq11 = 4.5 | People11 = Cameroon Bamileke
Freq12 = 4.0 | People12 = USA African America
Freq13 = 3.8 | People13 = Cameroon Sawa
Freq14 = 3.7 | People14 = South Africa Tswana
Freq15 = 3.6 | People15 = Mali Bandiagara
Freq16 = 2.8 | People16 = Iran Baloch
Freq17 = 2.7 | People17 = Zimbabwe Harare Shona
Freq18 = 2.3 | People18 = Zambia Lusaka
Freq19 = 2.2 | People19 = Senegal Niokholo Mandenka
Freq20 = 2.1 | People20 = Burkina Faso Rimaibe
Freq21 = 1.8 | People21 = Tunisia Ghannouch
Freq22 = 1.7 | People22 = Kenya Nandi
Freq23 = 1.6 | People23 = Brazil Parana Mulatto
Freq24 = 1.5 | People24 = Brazil
Freq25 = 1.4 | People25 = Morocco Nador Metalsa Cla…
Freq26 = 1.2 | People26 = Thailand Northeast
Freq27 = 1.2 | People27 = Venezuela Colonia Tovar
Freq28 = 1.1 | People28 = Brazil Belo Horizonte
Freq29 = 1.1 | People29 = Thailand
Freq30 = 1.1 | People30 = Tunisia Tunis
Freq31 = 1.1 | People31 = Turkey (1)AlleleFreq
Placement = left
Allele = A*7403
Freq1 = 2.8 | People1 = Kenya Luo
Freq2 = 0.6 | People2 = Argentina Toba Rosario
Freq3 = 0.6 | People3 = Iran Baloch
Freq4 = 0.5 | People4 = Saudi Arabia Guraiat and …
Freq5 = 0.3 | People5 = Kenya
Freq6 = 0.3 | People6 = Madeira
Freq7 = 0.3 | People7 = Uganda Kampala

ources

*cite journal |author=Madrigal JA, Belich MP, Hildebrand WH, "et al" |title=Distinctive HLA-A,B antigens of black populations formed by interallelic conversion |journal=J. Immunol. |volume=149 |issue=10 |pages=3411–5 |year=1992 |month=November |pmid=1431115 |doi= |url=http://www.ebi.ac.uk/~sp/intern/projects/pdf_archive/pdfpumped/5/1431115.pdf

References