Santa Cruz del Comercio

Infobox City
official_name = Santa Cruz del Comercio, Spain | nickname = |

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map_caption = Location of Santa Cruz del Comercio
subdivision_type = Country | subdivision_name = Spain | subdivision_type1 = Province | subdivision_name1 = Granada | subdivision_type2 = Municipality | subdivision_name2 = Santa Cruz del Comercio | leader_title = | leader_name = | area_magnitude = | area_total_km2 = 17 | area_land_km2 = | area_water_km2 = | elevation_m = 739 | population_as_of = 2005 | population_note = | population_total = 544 | population_density_km2 = 32.0 | timezone = CET | utc_offset = +1 | timezone_DST = CEST | utc_offset_DST = +2 | latitude = 37º03' N | longitude = 3º58' W | website = | footnotes = |

Santa Cruz del Comercio is a municipality located in the province of Granada, Spain. According to the 2005 census (INE), the city has a population of 544 inhabitants.