- Zebrafish Information Network
The Zebrafish Information Network ( [http://zfin.org/ ZFIN] ) is an online
biological databaseof information about the zebrafish("Danio rerio"). The zebrafish is a widely used model organismfor genetic, genomic, and developmental studies, and ZFIN provides an integrated interface for querying and displaying the large volume of data generated by this research. [Sprague "et al" (2008). [http://nar.oxfordjournals.org/cgi/content/abstract/36/suppl_1/D768 The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes.] "Nucleic Acids Res" 36:D768.] To facilitate use of the zebrafish as a model of humanbiology, ZFIN links these data to corresponding information in other model organism (e.g., mouse) and human disease databases. [ [http://zfin.org/zf_info/dbase/db.html The Zebrafish Database Project] ] Abundant links to external sequence databases (e.g., GenBank) and to genome browsers are included. Gene product, gene expression, and phenotype data are annotated with terms from biomedical ontologies, and ZFIN participates in one of the National Center for Biomedical Ontology's Driving Biological Projects. ZFIN is based at the University of Oregonin the United States, with funding provided by the National Institutes of Health(NIH).
ZFIN comprises two principal parts: (1) a website of community news and announcements, and biological resources such as laboratory protocols, a
gene nomenclatureguide, and anatomy information; and (2) a relational databaseof biological data that are curated from the scientific literature and of directly submitted data from zebrafish research laboratories (e.g., Thisse high-throughput gene expression analysis [B. Thisse and C. Thisse (2004). [http://zfin.org/cgi-bin/webdriver?MIval=aa-pubview2.apg&OID=ZDB-PUB-040907-1 Fast release clones: a high throughput expression analysis.] "ZFIN Direct Data Submission".] ). Information in ZFIN is tightly linked to the web resources of the Zebrafish International Resource Center ( [http://zebrafish.org/ ZIRC] ), which maintains and provides research resources and materials.
ZFIN's relational database interface consists of query forms and display pages for the following biological data types:
*Genes, markers, and clones
*Sequence alignments (
*Mutants and transgenic lines
ZFIN also maintains a database of zebrafish-related publications, laboratories, people, and companies. All information in ZFIN is also accessible via a global site search interface.
* [http://zfin.org/ ZFIN] The Zebrafish Model Organism Database
* [http://vega.sanger.ac.uk/Danio_rerio/index.html Vega Zebrafish Genome Annotation]
* [http://miracle.igib.res.in/cgi-bin/fishmap/gbrowse/ Fish
] maintained at the Institute of Genomics and Integrative Biology
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