Discovering Dengue Drugs – Together

Discovering Dengue Drugs – Together (DDDT) is a World Community Grid project sponsored by scientists at the University of Texas and the University of Chicago. Its goal is to identify new antiviral drugs effective against viruses from the family flaviviridae. The specific targets are:cite web
url=http://www.worldcommunitygrid.org/projects_showcase/dddt/viewDddtAbout.do
title=Discovering Dengue Drugs – Together: About the Project
publisher=World Community Grid
accessdate=2007-08-24]
* Dengue virus
* Hepatitis C virus
* West Nile virus
* Yellow fever virus

Discovering Dengue Drugs – Together will run in two phases. [cite web
url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=14561#109721
title=Re: Project about dengue ever
author=Didactylos
publisher=World Community Grid
date=2007-06-21
accessdate=2007-08-07] Phase 1, launched August 21, 2007, [cite web
url=http://www.worldcommunitygrid.org/projects_showcase/viewResearch.do
title=Active Research
work=Research
publisher=World Community Grid
accessdate-2007-07-28] uses AutoDock 2007 (the same software used for FightAIDS@Home) to test how well antiviral drug candidates are predicted to bind to the target virus's proteases. Compounds predicted to bind strongly (protease inhibitors) are potential antiviral drug candidates.

Phase 2 "will use a more computationally intensive program to screen the candidates that make it through Phase 1."cite web
url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15192#114871
title=Re: Results...
author=lawrencehardin
publisher=World Community Grid
date=2007-07-10
accessdate=2007-08-07] The drug candidates that make it through Phase 2 will then be lab-tested.

References

External links

* [http://www.utmb.edu/discoveringdenguedrugs%2Dtogether/ Discovering Dengue Drug-Together : Project Summary]
* [http://www.worldcommunitygrid.org/projects_showcase/dddt/viewDddtMain.do World Community Grid - Research - Discovering Dengue Drugs - Together]
* [http://www.ibm.com/ibm/ibmgives/news/dengue_fever.shtml World Community Grid launches global computing effort to find cures for dengue, West Nile, and hepatitis C diseases]
* [http://blog.utmb.edu/newsroom/?p=2286 UTMB and IBM enlist aid of global computer grid to find cures for dengue, West Nile and hepatitis C diseases]
* [http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15784#20070821 Launch of Discovering Dengue Drugs - Together Project]