HLA-DQ9

heteroisoform
isoformgroup = HLA-DQ9
polymer_type = MHC Class II, DQ cell surface antigen


image_source = Illustration of HLA-DQ with bound peptide.
isoformCount = 2
subunit1 = DQA1
subunit2 = DQB1
isoform1 = DQ α²β⁹
nick1 = DQ9.2
allele1a = HQAA|0201
allele1b = *0303
isoform2 = DQ α³β⁹
nick2 = DQ9.3
allele2a = HQAA|0302
allele2b = *0303
rareIsoforms = 0

HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a of the DQ3 . DQ8 is determined by the antibody recognition of β⁹ and this generally detects the gene product of DQB1*0303.

erology

The serotyping efficiency of DQ9 is poor. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DQB1 subgroup recognizes DQB1*0303 as efficiently as DQ3. For this reason DQ9 serotyping is a poor method of typing for transplantation or disease association prediction or study.

DQB1*0303

(DQ9) is associated with nasal polyps,cite journal | author = Zhai L, Sun Y, Tang L, Liu H | title = Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps | journal = Ann. Otol. Rhinol. Laryngol. | volume = 116 | issue = 1 | pages = 66–8 | year = 2007 | pmid = 17305280 | doi = ] gestational diabetes,cite journal | author = Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M | title = Different HLA-DR-DQ and MHC class I chain-related gene A (MICA) genotypes in autoimmune and nonautoimmune gestational diabetes in a Swedish population | journal = Hum. Immunol. | volume = 65 | issue = 12 | pages = 1443–50 | year = 2004 | pmid = 15603871 | doi = 10.1016/j.humimm.2004.09.002] microscopic polyangiitis (Japanese). Primary linkage is with DRB1*0901-DQB1*0303 cite journal | author = Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K | title = Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese | journal = Genes Immun. | volume = 7 | issue = 1 | pages = 81–4 | year = 2006 | pmid = 16208405 | doi = 10.1038/sj.gene.6364262 | issn = ]

Haplotypes and disease

DQ9.2

DQA1*0201:DQB1*0303 is associated with type I psoriasis (vulgaris),cite journal | author = Schmitt-Egenolf M, Boehncke WH, Ständer M, Eiermann TH, Sterry W | title = Oligonucleotide typing reveals association of type I psoriasis with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 extended haplotype | journal = J. Invest. Dermatol. | volume = 100 | issue = 6 | pages = 749–52 | year = 1993 | pmid = 8496614 | doi = ] cite journal | author = Zhang X, Wei S, Yang S, "et al" | title = HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han | journal = Int. J. Dermatol. | volume = 43 | issue = 3 | pages = 181–7 | year = 2004 | pmid = 15009387 | doi = ]

DQ9.3

DQA1*0302:DQB1*0303 maybe associated with juvenile diabetes in the orient.cite journal | author = Maruyama T, Shimada A, Kasuga A, "et al" | title = Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay | journal = Diabetes Res. Clin. Pract. | volume = 23 | issue = 2 | pages = 77–84 | year = 1994 | pmid = 8070305 | doi = ] cite journal | author = Ikegami H, Kawaguchi Y, Yamato E, "et al" | title = Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus | journal = J. Clin. Endocrinol. Metab. | volume = 75 | issue = 5 | pages = 1381–5 | year = 1992 | pmid = 1358911 | doi = ] (Chinese) Primary linkage of vitiligo is with DQA1*03-DQB1*0303cite journal | author = Xia Q, Zhou WM, Liang YH, "et al" | title = MHC haplotypic association in Chinese Han patients with vitiligo | journal = Journal of the European Academy of Dermatology and Venereology : JEADV | volume = 20 | issue = 8 | pages = 941–6 | year = 2006 | pmid = 16922942 | doi = 10.1111/j.1468-3083.2006.01686.x]

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