TGFB1

Transforming growth factor, beta 1, also known as TGFB1, is a human gene. PBB_Summary
section_title =
summary_text = TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems. [supplied by OMIM] [cite web | title = Entrez Gene: TGFB1 transforming growth factor, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7040| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Border WA, Noble NA |title=Transforming growth factor beta in tissue fibrosis. |journal=N. Engl. J. Med. |volume=331 |issue= 19 |pages= 1286–92 |year= 1994 |pmid= 7935686 |doi=
*cite journal | author=Munger JS, Harpel JG, Gleizes PE, "et al." |title=Latent transforming growth factor-beta: structural features and mechanisms of activation. |journal=Kidney Int. |volume=51 |issue= 5 |pages= 1376–82 |year= 1997 |pmid= 9150447 |doi=
*cite journal | author=Iozzo RV |title=The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 18843–6 |year= 1999 |pmid= 10383378 |doi=
*cite journal | author=Reinhold D, Wrenger S, Kähne T, Ansorge S |title=HIV-1 Tat: immunosuppression via TGF-beta1 induction. |journal=Immunol. Today |volume=20 |issue= 8 |pages= 384–5 |year= 1999 |pmid= 10431160 |doi=
*cite journal | author=Yamada Y |title=Association of polymorphisms of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis. |journal=Pharmacogenetics |volume=11 |issue= 9 |pages= 765–71 |year= 2002 |pmid= 11740340 |doi=
*cite journal | author=Chen W, Wahl SM |title=TGF-beta: receptors, signaling pathways and autoimmunity. |journal=Curr. Dir. Autoimmun. |volume=5 |issue= |pages= 62–91 |year= 2002 |pmid= 11826761 |doi=
*cite journal | author=Marone M, Bonanno G, Rutella S, "et al." |title=Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21. |journal=Leuk. Lymphoma |volume=43 |issue= 1 |pages= 51–7 |year= 2003 |pmid= 11908736 |doi=
*cite journal | author=Schnaper HW, Hayashida T, Hubchak SC, Poncelet AC |title=TGF-beta signal transduction and mesangial cell fibrogenesis. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 2 |pages= F243–52 |year= 2003 |pmid= 12529270 |doi= 10.1152/ajprenal.00300.2002
*cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776–84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530
*cite journal | author=Grainger DJ |title=Transforming growth factor beta and atherosclerosis: so far, so good for the protective cytokine hypothesis. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 3 |pages= 399–404 |year= 2005 |pmid= 14699019 |doi= 10.1161/01.ATV.0000114567.76772.33
*cite journal | author=Attisano L, Labbé E |title=TGFbeta and Wnt pathway cross-talk. |journal=Cancer Metastasis Rev. |volume=23 |issue= 1-2 |pages= 53–61 |year= 2004 |pmid= 15000149 |doi=
*cite journal | author=McGowan TA, Zhu Y, Sharma K |title=Transforming growth factor-beta: a clinical target for the treatment of diabetic nephropathy. |journal=Curr. Diab. Rep. |volume=4 |issue= 6 |pages= 447–54 |year= 2005 |pmid= 15539010 |doi=
*cite journal | author=Sheppard D |title=Integrin-mediated activation of latent transforming growth factor beta. |journal=Cancer Metastasis Rev. |volume=24 |issue= 3 |pages= 395–402 |year= 2006 |pmid= 16258727 |doi= 10.1007/s10555-005-5131-6
*cite journal | author=Gressner AM, Weiskirchen R |title=Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. |journal=J. Cell. Mol. Med. |volume=10 |issue= 1 |pages= 76–99 |year= 2006 |pmid= 16563223 |doi=
*cite journal | author=Seoane J |title=Escaping from the TGFbeta anti-proliferative control. |journal=Carcinogenesis |volume=27 |issue= 11 |pages= 2148–56 |year= 2006 |pmid= 16698802 |doi= 10.1093/carcin/bgl068
*cite journal | author=Lee CG, Kang HR, Homer RJ, "et al." |title=Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling. |journal=Proceedings of the American Thoracic Society |volume=3 |issue= 5 |pages= 418–23 |year= 2006 |pmid= 16799085 |doi= 10.1513/pats.200602-017AW
*cite journal | author=Wahl SM |title=Transforming growth factor-beta: innately bipolar. |journal=Curr. Opin. Immunol. |volume=19 |issue= 1 |pages= 55–62 |year= 2007 |pmid= 17137775 |doi= 10.1016/j.coi.2006.11.008
*cite journal | author=Redondo S, Santos-Gallego CG, Tejerina T |title=TGF-beta1: a novel target for cardiovascular pharmacology. |journal=Cytokine Growth Factor Rev. |volume=18 |issue= 3-4 |pages= 279–86 |year= 2007 |pmid= 17485238 |doi= 10.1016/j.cytogfr.2007.04.005

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