- Abraham de Bellebat, marquis du Quesne, governor of Martinique in 1716
- Abraham Duquesne, French admiral
- Calleigh Duquesne, a character in the television series CSI: Miami
- Fritz Joubert Duquesne, Boer/German spy who allegedly was responsible for the death of Field Marshal Kitchener in 1916
- Michel-Ange Duquesne de Menneville, governor of New France (Canada)
- Jean Du Quesne, the elder
- Jean Du Quesne the Younger
- Duquesne, Arizona, now a ghost town
- Duquesne, Missouri
- Duquesne, Pennsylvania, named after Marquis Duquesne
- Duquesne (PRR), a Pennsylvania Railroad passenger train, later renamed the Keystone by Amtrak
- French ship Duquesne, eight ships and one cruiser class in the French Navy named after Abraham Duquesne
- Skylark DuQuesne, a science fiction novel by E. E. "Doc" Smith
- DuQuesne Base, a forward operations base of the People's Republic of Haven in the Honorverse.
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