Zymosan

Zymosan

Zymosan is a glucan. It binds to TLR 2. [cite journal |author=Sato M, Sano H, Iwaki D, "et al" |title=Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A |journal=J. Immunol. |volume=171 |issue=1 |pages=417–25 |year=2003 |pmid=12817025 |doi=]

Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. [http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/Z4250]

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  • zymosan — noun Etymology: zym + osan (as in hexosan) Date: 1943 an insoluble largely polysaccharide fraction of yeast cell walls …   New Collegiate Dictionary

  • zymosan — Particulate yeast cell wall polysaccharide (mannan rich) that will activate complement in serum through the alternate pathway. Becomes coated with C3b/C3bi and is therefore a convenient opsonized particle; also leads to C5a production in the… …   Dictionary of molecular biology

  • zymosan — zy·mo·san (zīʹmə săn ) n. An insoluble carbohydrate from the cell wall of yeast, used especially in the immunoassay of properdin.   [zymosis + an2.] * * * …   Universalium

  • zymosan — noun an insoluble carbohydrate, obtained from the cell walls of yeast, used in the bioassay of blood serum …   Wiktionary

  • zymosan — A carbohydrate (glucose polymer) obtained from the walls of yeast cells that interferes with complement. * * * zy·mo·san zī mə .san n an insoluble largely polysaccharide fraction of yeast cell walls * * * zy·mo·san (ziґmo sən) a mixture of… …   Medical dictionary

  • zymosan — zy·mo·san …   English syllables

  • zymosan — ˈzīməˌsan noun ( s) Etymology: zymosis + an : a largely carbohydrate fraction of the yeast cell that is used in the assay of properdin …   Useful english dictionary

  • ZAS — zymosan activated autologous serum …   Medical dictionary

  • ZTS — zymosan treated serum …   Medical dictionary

  • ZyC — zymosan complement …   Medical dictionary

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