David Charles Baulcombe

Infobox Scientist |name =David Charles Baulcombe
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birth_date =1952
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field =genetic, gene silencing
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known_for =small interfering RNA
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David Charles Baulcombe (born 1952) is a plant scientist and geneticist with interests in genetic regulation, genetic disease resistance and gene silencing. With Andrew Hamilton he discovered the small interfering RNA that is the specificity determinant in RNA-mediated gene silencing and, with other members of his research group, he helped unravel the importance of small interfering RNA in defense against viruses and in epigenetics.

Baulcombe's career as an independent scientist started at the Plant Breeding Institute in Cambridge and continued between 1988 and 2007 at the Sainsbury Laboratory in Norwich. In March 2007, it was announced that Baulcombe would be the next Professor of Botany at Cambridge University, taking up his post in September 2007. [ [http://www.plantsci.cam.ac.uk/news/content.html Cambridge University Department of Plant Sciences news] ] He was elected to the Royal Society in 2001 and the United States National Academy of Sciences in 2005. His honours and awards include the Royal Netherlands Academy of Arts and Sciences's M. W. Beijerinck Virology Prize (2004), the Royal Society's Royal Medal (2006), and in 2008 he was co-recipient of The Franklin Institute's Benjamin Franklin Medal in Life Science. [http://www.fi.edu/franklinawards/08/laureate_bf_lifescience-ambros-baulcombe-ruvkin.html]

As of 2007, Baulcombe is a senior editor for The Embo Journal. [ [http://www.nature.com/emboj/editors_editorial_board.html Embo editorial board] ]

Publications

*Citation
id = PMID:12198169
url= http://www.ncbi.nlm.nih.gov/pubmed/12198169
last=Hamilton
first=Andrew
last2=Voinnet
first2=Olivier
last3=Chappell
first3=Louise
last4=Baulcombe
first4=David
publication-date=2002 Sep 2
year=2002
title=Two classes of short interfering RNA in RNA silencing.
volume=21
issue=17
periodical=EMBO J.
pages=4671-9
*Citation
id = PMID:11376158
url= http://www.ncbi.nlm.nih.gov/pubmed/11376158
last=Papaefthimiou
first=I
last2=Hamilton
first2=A
last3=Denti
first3=M
last4=Baulcombe
first4=D
publication-date=2001 Jun 1
year=2001
title=Replicating potato spindle tuber viroid RNA is accompanied by short RNA fragments that are characteristic of post-transcriptional gene silencing.
volume=29
issue=11
periodical=Nucleic Acids Res.
pages=2395-400
*Citation
id = PMID:10850496
url= http://www.ncbi.nlm.nih.gov/pubmed/10850496
last=Dalmay
first=T
last2=Hamilton
first2=A
last3=Rudd
first3=S
last4=Angell
first4=S
publication-date=2000 May 26
year=2000
title=An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus.
volume=101
issue=5
periodical=Cell
pages=543-53
*Citation
id = PMID:10810144
url= http://www.ncbi.nlm.nih.gov/pubmed/10810144
last=Burton
first=R A
last2=Gibeaut
first2=D M
last3=Bacic
first3=A
last4=Findlay
first4=K
publication-date=2000 May
year=2000
title=Virus-induced silencing of a plant cellulose synthase gene.
volume=12
issue=5
periodical=Plant Cell
pages=691-706
*Citation
id = PMID:10715323
url= http://www.ncbi.nlm.nih.gov/pubmed/10715323
last=Dalmay
first=T
last2=Hamilton
first2=A
last3=Mueller
first3=E
last4=Baulcombe
first4=D C
publication-date=2000 Mar
year=2000
title=Potato virus X amplicons in arabidopsis mediate genetic and epigenetic gene silencing.
volume=12
issue=3
periodical=Plant Cell
pages=369-79
*Citation
id = PMID:10590159
url= http://www.ncbi.nlm.nih.gov/pubmed/10590159
last=Jones
first=L
last2=Hamilton
first2=A J
last3=Voinnet
first3=O
last4=Thomas
first4=C L
publication-date=1999 Dec
year=1999
title=RNA-DNA interactions and DNA methylation in post-transcriptional gene silencing.
volume=11
issue=12
periodical=Plant Cell
pages=2291-301
*Citation
id = PMID:10542148
url= http://www.ncbi.nlm.nih.gov/pubmed/10542148
id = PMID:10577233
url= http://www.ncbi.nlm.nih.gov/pubmed/10577233
last=Hamilton
first=A J
last2=Baulcombe
first2=D C
publication-date=1999 Oct 29
year=1999
title=A species of small antisense RNA in posttranscriptional gene silencing in plants.
volume=286
issue=5441
periodical=Science
pages=950-2
*Citation
id = PMID:3668507
url= http://www.ncbi.nlm.nih.gov/pubmed/3668507
last=Hamilton
first=W D
last2=Boccara
first2=M
last3=Robinson
first3=D J
last4=Baulcombe
first4=D C
publication-date=1987 Oct
year=1987
title=The complete nucleotide sequence of tobacco rattle virus RNA-1.
volume=68 ( Pt 10)
issue=
periodical=J. Gen. Virol.
pages=2563-75
*Citation
id = PMID:16453668
url= http://www.ncbi.nlm.nih.gov/pubmed/16453668
last=Boccara
first=
last2=Hamilton
first2=
last3=Baulcombe
first3=
publication-date=1986 Feb
year=1986
title=The organisation and interviral homologies of genes at the 3' end of tobacco rattle virus RNA1.
volume=5
issue=2
pages=223-229

References

External links

* [http://www.in-cites.com/papers/DavidBaulcombe.html Interview with Professor Balcombe from in-cites website]
* [http://www.apsnet.org/members/awards/pdf/2002awardees.pdf Biography from the American Phytopathological Society 2002 Awards (p.4)]