Biopterin

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ImageFile=Biopterin.svg
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Section1= Chembox Identifiers
CASNo=22150-76-1
PubChem=2380
SMILES=CC(C(C1=CN=C2C(=N1) C(=O)N=C(N2)N)O)O
MeSHName=Biopterin
Section2= Chembox Properties
Formula=C₉H₁₁N₅O₃
MolarMass=237.216 g/mol
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Biopterin is a coenzyme that is produced within the body.

It is an oxidized degredation product of tetrahydrobiopterin.

Defects in biopterin synthesis or regeneration can cause a form of hyperphenylalaninemia (a disease with symptoms similar to PKU) [ [http://www.uic.edu/classes/phar/phar332/Clinical_Cases/aa%20metab%20cases/PKU%20Cases/bioh4.htm Tetrahydrobiopterin ] ] .

Biopterin is synthesized in several parts of the body, including the pineal gland [ [http://www.sciencemag.org/cgi/content/abstract/213/4512/1129 Biosynthesis of biopterin: adrenergic cyclic adenosine monophosphate-dependent inhibition in the pineal gland - Kapatos et al. 213 (4512): 1129 - Science ] ] .

Biopterin deficiency has been associated with a variety of disorders, including dystonia [ [http://intl.neurology.org/cgi/content/abstract/38/5/707 Dystonia with marked diurnal variation associated with biopterin deficiency - Fink et al. 38 (5): 707 - Neurology ] ] and rabiesRodney E. Willoughby, Jr., "A Cure for Rabies?" "Scientific American", V. 256, No. 4, April 2007, p. 95 ( [http://sciam.com/article.cfm?chanID=sa006&colID=1&articleID=5BCA4D82-E7F2-99DF-33323DF6FF21871F online link] )] .

References