Discriminant function

Discriminant function

Discriminant function (also called modified Maddrey's discriminant function) was originally described by Maddrey and Boitnott [cite journal |author=Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI |title=Corticosteroid therapy of alcoholic hepatitis |journal=Gastroenterology |volume=75 |issue=2 |pages=193–9 |year=1978 |pmid=352788 |doi=] to predict prognosis in alcoholic hepatitis. It is calculated by a simple formula:

{4}.{6} imes left [ prothombin time - control value (seconds) ight ] + serum bilirubin (mg/dl),

Prospective studies have shown that, it is useful in predicting short term prognosis especially mortality within 30 days [cite journal |author=Sheth M, Riggs M, Patel T |title=Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis |journal=BMC gastroenterology |volume=2 |issue= |pages=2 |year=2002 |pmid=11835693 |doi=] . A value more than 32 implies poor outcome with one month mortality ranging between 35% to 45% [cite journal |author=Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O |title=Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial |journal=Gastroenterology |volume=119 |issue=6 |pages=1637–48 |year=2000 |pmid=11113085 |doi=] .

To calculate Maddrey discriminant function using SI units - micromol/l (ie not US) divide bilirubin value by 88.4

See also

*Model for End-Stage Liver Disease
*Child-Pugh score

Reference list


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Discriminant function analysis — is a statistical analysis to predict a categorical dependent variable by one or more continuous or binary independent variables. It is different from an ANOVA or MANOVA, which is used to predict one (ANOVA) or multiple (MANOVA) continuous… …   Wikipedia

  • discriminant function — Statistics. a linear function of measurements of different properties of an object or event that is used to assign the object or event to one population or another (discriminant analysis). [1935 40] * * * …   Universalium

  • discriminant function — noun Date: circa 1936 a function of a set of variables that is evaluated for samples of events or objects and used as an aid in discriminating between or classifying them …   New Collegiate Dictionary

  • discriminant function — noun : a function of a set of variables (as measurements of taxonomic specimens) that is evaluated for samples of events or objects and used as an aid in discriminating between or classifying them …   Useful english dictionary

  • Modified Maddrey's discriminant function — The modified Maddrey s discriminant function) was originally described by Maddrey and Boitnott[1] to predict prognosis in alcoholic hepatitis. It is calculated by a simple formula: Prospective studies have shown that, it is useful in predicting… …   Wikipedia

  • discriminant function analysis — a form of multivariate analysis useful when the dependent variable is nominal or dichotomous and the independent variables are continuous; used to find the combination of variables that maximizes the separation between categories for the… …   Medical dictionary

  • Discriminant — Dis*crim i*nant, n. [L. discriminans, p. pr. of discriminare.] (Math.) The eliminant of the n partial differentials of any homogenous function of n variables. See {Eliminant}. [1913 Webster] …   The Collaborative International Dictionary of English

  • Discriminant — In algebra, the discriminant of a polynomial is an expression which gives information about the nature of the polynomial s roots. For example, the discriminant of the quadratic polynomial is Here, if Δ > 0, the polynomial has two real roots,… …   Wikipedia

  • Discriminant of an algebraic number field — A fundamental domain of the ring of integers of the field K obtained from Q by adjoining a root of x3 − x2 − 2x + 1. This fundamental domain sits inside K ⊗QR. The discriminant of K is 49 = 72.… …   Wikipedia

  • discriminant — discriminantal /dis krim euh nan tl/, adj. /di skrim euh neuhnt/, n. Math. a relatively simple expression that determines some of the properties, as the nature of the roots, of a given equation or function. [1830 40; < L discriminant (s. of… …   Universalium

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”