Discriminant function

Discriminant function

Discriminant function (also called modified Maddrey's discriminant function) was originally described by Maddrey and Boitnott [cite journal |author=Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI |title=Corticosteroid therapy of alcoholic hepatitis |journal=Gastroenterology |volume=75 |issue=2 |pages=193–9 |year=1978 |pmid=352788 |doi=] to predict prognosis in alcoholic hepatitis. It is calculated by a simple formula:

{4}.{6} imes left [ prothombin time - control value (seconds) ight ] + serum bilirubin (mg/dl),

Prospective studies have shown that, it is useful in predicting short term prognosis especially mortality within 30 days [cite journal |author=Sheth M, Riggs M, Patel T |title=Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis |journal=BMC gastroenterology |volume=2 |issue= |pages=2 |year=2002 |pmid=11835693 |doi=] . A value more than 32 implies poor outcome with one month mortality ranging between 35% to 45% [cite journal |author=Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O |title=Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial |journal=Gastroenterology |volume=119 |issue=6 |pages=1637–48 |year=2000 |pmid=11113085 |doi=] .

To calculate Maddrey discriminant function using SI units - micromol/l (ie not US) divide bilirubin value by 88.4

See also

*Model for End-Stage Liver Disease
*Child-Pugh score

Reference list


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