TrkB IRES

TrkB IRES

The TrkB internal ribosome entry site (IRES) is an RNA element which is present in the 5' UTR sequence of the mRNA. TrkB is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The internal ribosome entry site IRES element allows cap-independent translation of TrkB which may be needed for efficient translation in neuronal dendrites. [cite journal | last = Dobson | first = T | coauthors = Minic A, Nielsen K, Amiott E, Krushel L | year = 2005 | title = Internal initiation of translation of the TrkB mRNA is mediated by multiple regions within the 5' leader | journal = Nucleic Acids Res | volume = 33 | pages = 2929–2941 | pmid = 15908588 | doi = 10.1093/nar/gki605]

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