Tombusvirus internal replication element (IRE)

Tombusvirus internal replication element (IRE)

In virology, the tombusvirus internal replication element (IRE) is a segment of RNA located within the region coding for p92 polymerase. This element is essential for viral replication; specifically, it is thought to be required at an early stage of replication, such as template recruitment and/or replicase complex assembly. [cite journal | last = Monkewich | first = S | coauthors = Lin HX, Fabian MR, Xu W, Na H, Ray D, Chernysheva OA, Nagy PD, White KA | year = 2005 | title = The p92 Polymerase Coding Region Contains an Internal RNA Element Required at an Early Step in Tombusvirus Genome Replication | journal = J Virol | volume = 79 | pages = 4848–4858 | pmid = 15795270 | doi = 10.1128/JVI.79.8.4848-4858.2005]

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