Tobamovirus internal ribosome entry site (IRES)

This family represents the Tobamovirus internal ribosome entry site (IRES). [cite journal | last = Ivanov | first = PA | coauthors = Karpova OV, Skulachev MV, Tomashevskaya OL, Rodionova NP, Dorokhov YuL, Atabekov JG | year = 1997 | title = A tobamovirus genome that contains an internal ribosome entry site functional in vitro | journal = Virology | volume = 232 | pages = 32–43 | pmid = 9185586 | doi = 10.1006/viro.1997.8525] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F. [cite journal | last = Kolupaeva | first = VG | coauthors = Pestova TV, Hellen CU | year = 2000 | title = Ribosomal binding to the internal ribosomal entry site of classical swine fever virus | journal = RNA | volume = 6 | pages = 1791–1807 | pmid = 11142379 | doi = 10.1017/S1355838200000662]

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