Small nucleolar RNA Z199

snoRNA Z199 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA Z199 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-ribose methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] . snoZ199 is precicted to be a methylation guide for sites on 18S and 25S ribosomal RNA (rRNA). "Oryza sativa" snoZ199 is reported to be homologous to "Arabidopsis thaliana" snoR13 [cite journal | last = Chen | first = CL | coauthors = Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH | year = 2003 | title = The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa | journal = Nucleic Acids Res | volume = 31 | pages = 2601–2613 | pmid = 12736310 | doi = 10.1093/nar/gkg373] .

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