Small nucleolar RNA SNORD87

SNORD87 (also known as U87) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U87 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] . cite journal | author = Kiss T | title = Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions | journal = Cell | volume = 109 | issue = 2 | pages = 145–8 | year = 2002 | pmid = 12007400 | doi = | issn = ]

U87 was identified by purification from yeast ("Saccharomyces cerevisiae") cite journal | author = Gogolevskaya IK, Makarova JA, Gause LN, Kulichkova VA, Konstantinova IM, Kramerov DA | title = U87 RNA, a novel C/D box small nucleolar RNA from mammalian cells | journal = Gene | volume = 292 | issue = 1-2 | pages = 199–204 | year = 2002 | pmid = 12119114 | doi = | issn = ] and is the orthologue of mouse MBII-276 cite journal | last = Huttenhofer | first = A | coauthors = Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J | year = 2001 | title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse | journal = EMBO J. | volume = 20 | pages = 2943–2953 | pmid = 11387227 | doi = 10.1093/emboj/20.11.2943 ]

References

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=HBII-276 snoRNABase entry for SNORD87]