Small nucleolar RNA SNORD29

SNORD29 (also known as U29) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

U29 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] cite journal | author = Kiss T | title = Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions | journal = Cell | volume = 109 | issue = 2 | pages = 145–8 | year = 2002 | pmid = 12007400 | doi = 10.1016/S0092-8674(02)00718-3| issn = ] .

In humans U29 and several other snoRNAs (U22 and U25-U31) are located in the introns of the same gene (called UHG for U22 host gene) cite journal | author = Tycowski KT, Shu MD, Steitz JA | title = A mammalian gene with introns instead of exons generating stable RNA products | journal = Nature | volume = 379 | issue = 6564 | pages = 464–6 | year = 1996 | pmid = 8559254 | doi = 10.1038/379464a0 | issn = ] cite journal | author = Tycowski KT, Smith CM, Shu MD, Steitz JA | title = A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 25 | pages = 14480–5 | year = 1996 | pmid = 8962077 | doi = 10.1073/pnas.93.25.14480| issn = ] . U29 is proposed to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residue A4493 cite journal | author = Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T | title = Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs | journal = Cell | volume = 85 | issue = 7 | pages = 1077–88 | year = 1996 | pmid = 8674114 | doi = 10.1016/S0092-8674(00)81308-2| issn = ] cite journal | last = Lestrade | first = L | coauthors = Weber MJ | year = 2006 | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | pages = D158–D162 | pmid = 16381836 | doi = 10.1093/nar/gkj002 ] .

References

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=U29 snoRNABase entry for SNORD29]