Small nucleolar RNA SNORD27

Small nucleolar RNA SNORD27 (U27) is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. U27 is encoded within the U22 snoRNA host gene (UHG) in mammals [cite journal | last = Tycowski | first = KT | coauthors = Shu MD, Steitz JA | year = 1996 | title = A mammalian gene with introns instead of exons generating stable RNA products | journal = Nature | volume = 379 | pages = 464–466 | pmid = 8559254 | doi = 10.1038/379464a0] and is thought to act as a 2'-O-ribose methylation guide for ribosomal RNA. [cite journal | last = Tycowski | first = KT | coauthors = Smith CM, Shu MD, Steitz JA | year = 1996 | title = A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus | journal = Proc Natl Acad Sci U S A | volume = 93 | pages = 14480–14485 | pmid = 8962077 | doi = 10.1073/pnas.93.25.14480] This family also contains several related snoRNAs from yeast and plants.

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