HIF-1 alpha IRES

The HIF-1α internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of HIF-1α that allows cap-independent translation. The HIF-1α internal ribosome entry site (IRES) allows translation to be maintained under hypoxic cell conditions that inhibit cap-dependent translation [1] . The hypoxia-inducible factor-1α protein (HIF-1α) is a subunit of the HIF-1 transcription factor, which induces transcription of several genes involved in the cellular response to hypoxia.

References

* [1] cite journal | last = Lang | first = KJ | coauthors = Kappel A, Goodall GJ | year = 2002 | title = Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia | journal = Mol Biol Cell | volume = 13 | pages = 1792–1801 | pmid = 12006670 | doi = 10.1091/mbc.02-02-0017

External links

*