Small nucleolar RNA Z196/R39/R59 family

Small nucleolar RNA Z196/R39/R59 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.snoRNA Z196/R39/R59 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .Plant snoRNA Z196 was identified in a screen of "Arabidopsis thaliana"cite journal | author = Marker C, Zemann A, Terhorst T, "et al" | title = Experimental RNomics: identification of 140 candidates for small non-messenger RNAs in the plant Arabidopsis thaliana | journal = Curr. Biol. | volume = 12 | issue = 23 | pages = 2002–13 | year = 2002 | pmid = 12477388 | doi = | issn = ] .

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