Small nucleolar RNA SNORA35

"Homo sapiens" snoRA35 (also known as HBI-36) is an H/ACA box snoRNA, first cloned from a mouse adult brain cDNA library by Cavaillé et al. (2000) [cite journal | last = Cavaille | first = J | coauthors = Buiting K, Kiefmann M, Lalande M, Brannan CI, Horsthemke B, Bachellerie JP, Brosius J, Huttenhofer A | year = 2000 | title = Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization | journal = Proc Natl Acad Sci U S A. | volume = 97 | pages = 14311–14316 | pmid = 11106375 | doi = 10.1073/pnas.250426397] , and found to be specifically expressed in the choroid plexus. Its human orthologue, HBI-36 was discovered by a homology search, and was found to be specifically expressed in the brain. Its gene resides in the second intron of the serotonin receptor 2c (5HT-2c) gene, which is predominantly expressed in choroid plexus epithelial cells. Interestingly, the human 5HT-2c mRNA was predicted to be 2'O-methylated by the C/D box snoRNP HBII-52 at a position also subjected to . HBI-36 has no documented RNA target.

References

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=HBI-36 snoRNABase entry for HBI-36]