Small nucleolar RNA R160

Samm nucleolar RNA R160 (also known as snoR160) is a non-coding RNA (ncRNA) molecule identified in plants which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoR160 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .

snoR160 was identified by computational screening of the rice "Oryza sativa" and is predicted to acts as a methylation guide for 25S ribosomal RNA in plants cite journal | author = Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH | title = The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa | journal = Nucleic Acids Res. | volume = 31 | issue = 10 | pages = 2601–13 | year = 2003 | pmid = 12736310 | doi = | issn = ] . snoR160 has also been alternatively named snoZ270 in rice.

References

External links

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* [http://bioinf.scri.sari.ac.uk/cgi-bin/plant_snorna/home plant snoRNA database]