Small nucleolar RNA MBI-28
- Small nucleolar RNA MBI-28
Small nucleolar RNA MBI-28 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'[cite journal |author=Kiss T |title=Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions |journal=Cell |volume=109 |issue=2 |pages=145–8 |year=2002 |pmid=12007400 |doi=] .snoRNA MBI-28 was originally cloned from mouse brain tissues][cite journal | author = Huttenhofer A, Kiefmann M, Meier-Ewert S, "et al" | title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse | journal = EMBO J. | volume = 20 | issue = 11 | pages = 2943–53 | year = 2001 | pmid = 11387227 | doi = 10.1093/emboj/20.11.2943 | issn = ] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and has the conserved H/ACA-box motifs. ]References
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