- Rubella virus 3' cis-acting element
This family represents a cis-acting element found at the 3' UTR in the
rubella virus . This family contains three conserved step loop structures. Pfam:PF00262 (CAL) which is known to bind calcium in mosteukaryotic cells, is able to specifically bind to the firststem loop . CAL binding is thought to be related to viralpathogenesis and in particulararthritis which is a occurs frequently in rubella infections in adults and is independent of viralviability . All stem loop structures are thought to be important for efficient viral replication and deletion of stem loop three is known to be lethal. [cite journal | last = Chen | first = MH | coauthors = Frey TK | year = 1999 | title = Mutagenic analysis of the 3' cis-acting elements of the rubella virus genome | journal = J Virol | volume = 73 | pages = 3386–3403 | pmid = 10074193]References
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