- Rubella virus 3' cis-acting element
This family represents a cis-acting element found at the 3' UTR in the
rubella virus. This family contains three conserved step loop structures. Pfam:PF00262 (CAL) which is known to bind calcium in most eukaryoticcells, is able to specifically bind to the first stem loop. CAL binding is thought to be related to viral pathogenesisand in particular arthritiswhich is a occurs frequently in rubella infections in adults and is independent of viral viability. All stem loop structures are thought to be important for efficient viral replication and deletion of stem loop three is known to be lethal. [cite journal | last = Chen | first = MH | coauthors = Frey TK | year = 1999 | title = Mutagenic analysis of the 3' cis-acting elements of the rubella virus genome | journal = J Virol | volume = 73 | pages = 3386–3403 | pmid = 10074193]
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